Improving Small Intestinal Motility in Experimental Acute Necrotising Pancreatitis by Modulating the CPI-17MLCP Pathway Using Chaiqin Chengqi Decoction
المؤلفون المشاركون
Phillips, Anthony R. J.
Lin, Ziqi
Xia, Qing
Shi, Na
Deng, Lihui
Jin, Tao
Jiang, Kun
Guo, Jia
Zhang, Chen-Long
Sutton, Robert
Windsor, John A.
Xue, Ping
Zhang, Xiaoxin
Wen, Yongjian
Han, Chengxia
Du, Dan
Liu, Tingting
Yang, Xiaonan
Huang, Wei
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-02-10
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Protein kinase C-potentiated inhibitor protein of 17 kDa (CPI-17), a specific inhibitor of myosin light-chain phosphatase (MLCP) regulated by proinflammatory cytokines, is central for calcium sensitisation.
We investigated the effects of chaiqin chengqi decoction (CQCQD) on the CPI-17/MLCP pathway in the small intestinal smooth muscle cells (SMCs) and strips (SMS) in an AP model.
Necrotising AP was induced in rats by intraperitoneal injections (IPI) of L-ornithine (3.0 g/kg, pH 7.0; hourly × 2) at 1 hour apart; controls received saline.
In treatment groups, carbachol (CCh; 60 μg/kg, IPI) or CQCQD (20 g/kg; 2-hourly × 3, intragastric) was administered.
The necrotising AP model was associated with systemic inflammation (serum IL-1β and TNF-α) and worsened jejunum histopathology and motility (serum vasoactive intestinal peptide and intestinal fatty acid-binding protein) as the disease progressed.
There was decreased intracellular calcium concentration ([Ca2+]i) SMCs.
Contractile function of isolated SMCs was reduced and associated with down-regulated expression of key mRNAs and proteins of the CPI-17/MLCP pathway as well as increased IL-1β and TNF-α.
CQCQD and CCh significantly reversed these changes and the disease severity.
These data suggest that CQCQD can improve intestinal motility by modulating the CPI-17/MLCP pathway in small intestinal smooth muscle during AP.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lin, Ziqi& Zhang, Chen-Long& Zhang, Xiaoxin& Shi, Na& Wen, Yongjian& Han, Chengxia…[et al.]. 2020. Improving Small Intestinal Motility in Experimental Acute Necrotising Pancreatitis by Modulating the CPI-17MLCP Pathway Using Chaiqin Chengqi Decoction. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1158400
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lin, Ziqi…[et al.]. Improving Small Intestinal Motility in Experimental Acute Necrotising Pancreatitis by Modulating the CPI-17MLCP Pathway Using Chaiqin Chengqi Decoction. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-14.
https://search.emarefa.net/detail/BIM-1158400
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lin, Ziqi& Zhang, Chen-Long& Zhang, Xiaoxin& Shi, Na& Wen, Yongjian& Han, Chengxia…[et al.]. Improving Small Intestinal Motility in Experimental Acute Necrotising Pancreatitis by Modulating the CPI-17MLCP Pathway Using Chaiqin Chengqi Decoction. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1158400
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1158400
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر