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Improving Small Intestinal Motility in Experimental Acute Necrotising Pancreatitis by Modulating the CPI-17MLCP Pathway Using Chaiqin Chengqi Decoction
المؤلفون المشاركون
Phillips, Anthony R. J.
Lin, Ziqi
Xia, Qing
Shi, Na
Deng, Lihui
Jin, Tao
Jiang, Kun
Guo, Jia
Zhang, Chen-Long
Sutton, Robert
Windsor, John A.
Xue, Ping
Zhang, Xiaoxin
Wen, Yongjian
Han, Chengxia
Du, Dan
Liu, Tingting
Yang, Xiaonan
Huang, Wei
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-02-10
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Protein kinase C-potentiated inhibitor protein of 17 kDa (CPI-17), a specific inhibitor of myosin light-chain phosphatase (MLCP) regulated by proinflammatory cytokines, is central for calcium sensitisation.
We investigated the effects of chaiqin chengqi decoction (CQCQD) on the CPI-17/MLCP pathway in the small intestinal smooth muscle cells (SMCs) and strips (SMS) in an AP model.
Necrotising AP was induced in rats by intraperitoneal injections (IPI) of L-ornithine (3.0 g/kg, pH 7.0; hourly × 2) at 1 hour apart; controls received saline.
In treatment groups, carbachol (CCh; 60 μg/kg, IPI) or CQCQD (20 g/kg; 2-hourly × 3, intragastric) was administered.
The necrotising AP model was associated with systemic inflammation (serum IL-1β and TNF-α) and worsened jejunum histopathology and motility (serum vasoactive intestinal peptide and intestinal fatty acid-binding protein) as the disease progressed.
There was decreased intracellular calcium concentration ([Ca2+]i) SMCs.
Contractile function of isolated SMCs was reduced and associated with down-regulated expression of key mRNAs and proteins of the CPI-17/MLCP pathway as well as increased IL-1β and TNF-α.
CQCQD and CCh significantly reversed these changes and the disease severity.
These data suggest that CQCQD can improve intestinal motility by modulating the CPI-17/MLCP pathway in small intestinal smooth muscle during AP.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lin, Ziqi& Zhang, Chen-Long& Zhang, Xiaoxin& Shi, Na& Wen, Yongjian& Han, Chengxia…[et al.]. 2020. Improving Small Intestinal Motility in Experimental Acute Necrotising Pancreatitis by Modulating the CPI-17MLCP Pathway Using Chaiqin Chengqi Decoction. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1158400
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lin, Ziqi…[et al.]. Improving Small Intestinal Motility in Experimental Acute Necrotising Pancreatitis by Modulating the CPI-17MLCP Pathway Using Chaiqin Chengqi Decoction. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-14.
https://search.emarefa.net/detail/BIM-1158400
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lin, Ziqi& Zhang, Chen-Long& Zhang, Xiaoxin& Shi, Na& Wen, Yongjian& Han, Chengxia…[et al.]. Improving Small Intestinal Motility in Experimental Acute Necrotising Pancreatitis by Modulating the CPI-17MLCP Pathway Using Chaiqin Chengqi Decoction. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1158400
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1158400
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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