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Synthesis and Characterization of Nanohydroxyapatite-Gelatin Composite with Streptomycin as Antituberculosis Injectable Bone Substitute
المؤلفون المشاركون
Hikmawati, Dyah
Maulida, Hendita N.
Putra, Alfian P.
Budiatin, Aniek S.
Syahrom, Ardiyansyah
المصدر
International Journal of Biomaterials
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-06-25
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
The most effective treatment for spinal tuberculosis was by eliminating the tuberculosis bacteria and replacing the infected bone with the bone graft to induce the healing process.
This study aims to synthesize and characterize nanohydroxyapatite-gelatin-based injectable bone substitute (IBS) with addition of streptomycin.
The IBS was synthesized by mixing nanohydroxyapatite and 20 w/v% gelatin with ratio of 40:60, 45:55, 50:50, 55:45, 60:40, 65:35, 70:30, and 75:25 ratio and streptomycin addition as antibiotic agent.
The mixture was added by hydroxypropyl methylcellulose as suspending agent.
FTIR test showed that there was a chemical reaction occurring in the mixture, between the gelatin and streptomycin.
The result of injectability test showed that the highest injectability of the IBS sample was 98.64% with the setting time between 30 minutes and four hours after injection on the HA scaffold that represents the bone cavity and coat the pore scaffold.
The cytotoxicity test result showed that the IBS samples were nontoxic towards BHK-21 fibroblast cells and human hepatocyte cells since the viability cell was more than 50% with significant difference (p-value<0.05).
The acidity of the IBS was stable and it was sensitive towards Staphylococcus aureus with significantly difference (p-value<0.05).
The streptomycin release test showed that the streptomycin could be released from the IBS-injected bone scaffold with release of 2.5% after 4 hours.
All the results mentioned showed that IBS was suitable as a candidate to be used in spinal tuberculosis case.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hikmawati, Dyah& Maulida, Hendita N.& Putra, Alfian P.& Budiatin, Aniek S.& Syahrom, Ardiyansyah. 2019. Synthesis and Characterization of Nanohydroxyapatite-Gelatin Composite with Streptomycin as Antituberculosis Injectable Bone Substitute. International Journal of Biomaterials،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1158408
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hikmawati, Dyah…[et al.]. Synthesis and Characterization of Nanohydroxyapatite-Gelatin Composite with Streptomycin as Antituberculosis Injectable Bone Substitute. International Journal of Biomaterials No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1158408
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hikmawati, Dyah& Maulida, Hendita N.& Putra, Alfian P.& Budiatin, Aniek S.& Syahrom, Ardiyansyah. Synthesis and Characterization of Nanohydroxyapatite-Gelatin Composite with Streptomycin as Antituberculosis Injectable Bone Substitute. International Journal of Biomaterials. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1158408
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1158408
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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