Icariin Attenuates Monocrotaline-Induced Pulmonary Arterial Hypertension via the Inhibition of TGF-β1Smads Pathway in Rats
المؤلفون المشاركون
Zhao, Huan
Zeng, Chun-lai
Cai, Changhong
Wu, Yonghui
Xiang, Yijia
Yang, Lebing
Ye, Shiyong
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-12-01
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
Pulmonary artery remodeling is important in the development of pulmonary artery hypertension.
The TGF-β1/Smads signaling pathway is activated in pulmonary arterial hypertension (PAH) in rats.
Icariin (ICA) suppresses the TGF-β1/Smad2 pathway in myocardial fibrosis in rats.
Therefore, we investigated the role of icariin in PAH by inhibiting the TGF-β1/Smads pathway.
Methods.
Rats were randomly divided into control, monocrotaline (MCT), MCT + ICA-low, and MCT + ICA-high groups.
MCT (60 mg/kg) was subcutaneously injected to induce PAH, and icariin (50 or 100 mg/kg.d) was orally administered for 2 weeks.
At the end of the fourth week, right ventricular systolic pressure (RVSP) was obtained and the right ventricular hypertrophy index (RI) was determined as the ratio of the right ventricular weight to the left ventricular plus septal weight (RV/LV + S).
Western blots were used to determine the expression of TGF-β1, Smad2/3, P-Smad2/3, and matrix metalloproteinase-2 (MMP2) in lung tissues.
Results.
Compared to the control group, RVSP and RI were increased in the MCT group (ρ < 0.05).
Additionally, TGF-β1, Smad2/3, P-Smad2/3, and MMP2 expressions were obviously increased (ρ < 0.01).
Compared to the MCT group, RVSP and RI were decreased in the MCT + ICA group (ρ < 0.05).
TGF-β1, Smad2/3, P-Smad2/3, and MMP2 expressions were also inhibited in the icariin treatment groups (ρ < 0.05).
Conclusions.
Icariin may suppress MCT-induced PAH via the inhibition of the TGFβ1-Smad2/3 pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xiang, Yijia& Cai, Changhong& Wu, Yonghui& Yang, Lebing& Ye, Shiyong& Zhao, Huan…[et al.]. 2020. Icariin Attenuates Monocrotaline-Induced Pulmonary Arterial Hypertension via the Inhibition of TGF-β1Smads Pathway in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1158421
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xiang, Yijia…[et al.]. Icariin Attenuates Monocrotaline-Induced Pulmonary Arterial Hypertension via the Inhibition of TGF-β1Smads Pathway in Rats. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1158421
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xiang, Yijia& Cai, Changhong& Wu, Yonghui& Yang, Lebing& Ye, Shiyong& Zhao, Huan…[et al.]. Icariin Attenuates Monocrotaline-Induced Pulmonary Arterial Hypertension via the Inhibition of TGF-β1Smads Pathway in Rats. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1158421
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1158421
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر