![](/images/graphics-bg.png)
Antihyperglycemic Effects and Mode of Actions of Musa paradisiaca Leaf and Fruit Peel Hydroethanolic Extracts in NicotinamideStreptozotocin-Induced Diabetic Rats
المؤلفون المشاركون
Abdel Aziz, Sarah M.
Ahmed, Osama M.
Abd EL-Twab, Sanaa M.
Al-Muzafar, Hessah Mohammed
Amin, Kamal Adel
Abdel-Gabbar, Mohamed
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-01-27
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
The present study aimed to evaluate the antihyperglycemic effects of Musa paradisiaca (M.
paradisiaca) leaf and fruit peel hydroethanolic extracts and to suggest their probable mode of actions in nicotinamide (NA)/streptozotocin (STZ)-induced diabetic rats.
The leaf and fruit peel hydroethanolic extracts were analyzed by GC-MS that indicated the presence of phytol, octadecatrienoic acid, hexadecanoic acid, and octadecadienoic acid as major components in the leaf extract and vitamin E, octadecenamide, β-sitosterol, and stigmasterol as major phytochemicals in the fruit peel extract.
Diabetes mellitus was induced by a single intraperitoneal injection of STZ (60 mg/kg body weight) dissolved in citrate buffer (pH 4.5), 15 minutes after intraperitoneal injection of NA (120 mg/kg body weight).
The NA/STZ-induced diabetic rats were, respectively, treated with M.
paradisiaca leaf and fruit peel hydroethanolic extracts at a dose of 100 mg/kg body weight/day by oral administration for 28 days.
The treatment of NA/STZ-induced diabetic rats with leaf and fruit peel extracts significantly improved the impaired oral glucose tolerance and significantly increased the lowered serum insulin and C-peptide levels.
The HOMA-IR (as the index of insulin resistance) and QUICKI (as a marker for insulin sensitivity), as well as HOMA-β cell function were significantly alleviated as a result of treatment of diabetic rats with leaf and fruit peel extracts.
In association, the elevated serum-free fatty acids, TNF-α, and IL-6 levels were significantly decreased.
In addition, the suppressed adipose tissue PPARγ, GLUT4, adiponectin, and insulin receptor β-subunit mRNA expressions were upregulated while the elevated adipose tissue resistin expression was downregulated in diabetic rats as a result of treatment with the leaf and peel extract.
Based on these results, it can be concluded that M.
paradisiaca leaf and fruit peel hydroethanolic extracts have antihyperglycemic effects which may be mediated via their insulinotropic and insulin-sensitizing effects.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abdel Aziz, Sarah M.& Ahmed, Osama M.& Abd EL-Twab, Sanaa M.& Al-Muzafar, Hessah Mohammed& Amin, Kamal Adel& Abdel-Gabbar, Mohamed. 2020. Antihyperglycemic Effects and Mode of Actions of Musa paradisiaca Leaf and Fruit Peel Hydroethanolic Extracts in NicotinamideStreptozotocin-Induced Diabetic Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1158440
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abdel Aziz, Sarah M.…[et al.]. Antihyperglycemic Effects and Mode of Actions of Musa paradisiaca Leaf and Fruit Peel Hydroethanolic Extracts in NicotinamideStreptozotocin-Induced Diabetic Rats. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-15.
https://search.emarefa.net/detail/BIM-1158440
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abdel Aziz, Sarah M.& Ahmed, Osama M.& Abd EL-Twab, Sanaa M.& Al-Muzafar, Hessah Mohammed& Amin, Kamal Adel& Abdel-Gabbar, Mohamed. Antihyperglycemic Effects and Mode of Actions of Musa paradisiaca Leaf and Fruit Peel Hydroethanolic Extracts in NicotinamideStreptozotocin-Induced Diabetic Rats. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1158440
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1158440
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)