Xiao-Qing-Long-Tang Maintains Cardiac Function during Heart Failure with Reduced Ejection Fraction in Salt-Sensitive Rats by Regulating the Imbalance of Cardiac Sympathetic Innervation
المؤلفون المشاركون
Li, Zhaoyu
Wang, Yongcheng
Jiang, Yuehua
Ma, Dufang
Zhou, Guofeng
Yang, Jinlong
Dong, Feng
Zhao, Hengyi
Zhang, Yimei
Li, Xiao
Jiang, Ping
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-11-24
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Objective.
The anatomical and functional imbalances of sympathetic nerves are associated with cardiovascular disease progression.
Xiao-Qing-Long-Tang (XQLT), an ancient Chinese herbal formula, has been used to treat cardiovascular diseases in eastern Asia for thousands of years.
We determined the effect of XQLT in maintaining cardiac function during heart failure with reduced ejection fraction (HFrEF) with respect to its neurobiological effects in salt-sensitive rats.
Methods.
Dahl salt-sensitive (DS) rats were fed a high-salt diet to establish an HFrEF model and were divided into model (DS, administered normal saline) and XQL groups (administrated XQLT) randomly, with SS-13BN rats being used as the control.
The bodyweight and blood pressure of rats were observed regularly.
Electrocardiogram, echocardiography, and plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP) were determined to assess cardiac function.
The sympathetic tune and myocardial morphological changes were evaluated.
Western blot and qRT-PCR were used to assay the expression of the nerve growth factor (NGF) and leukemia inhibitory factor (LIF).
Tyrosine hydroxylase (TH), choline acetyltransferase (CHAT), and growth-associated protein 43 (GAP43) were assayed to confirm sympathetic remodeling.
The micromorphological changes in cardiac sympathetic nerve endings were observed by transmission electron microscopy.
Results.
Four weeks after XQLT treatment, cardiac function and bodyweight were higher and blood pressure was lower than that of the DS group.
Myocardial noradrenaline (NA) increased, while the plasma NA level decreased significantly.
The morphology demonstrated that XQLT significantly alleviated myocardial damage.
XQLT decreased the expression of LIF, increased the expression of NGF, enhanced the TH+/GAP43+ and TH+/CHAT + positive nerve fiber density, and improved the TH and GAP43 protein expression, but had no effect on CHAT.
Moreover, XQLT improved the micromorphology of sympathetic nerve endings in the myocardium.
Conclusion.
XQLT maintains cardiac function during HFrEF in salt-sensitive rats, in part, by regulating the imbalance of cardiac sympathetic innervation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Zhaoyu& Wang, Yongcheng& Jiang, Yuehua& Ma, Dufang& Jiang, Ping& Zhou, Guofeng…[et al.]. 2020. Xiao-Qing-Long-Tang Maintains Cardiac Function during Heart Failure with Reduced Ejection Fraction in Salt-Sensitive Rats by Regulating the Imbalance of Cardiac Sympathetic Innervation. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1158523
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Zhaoyu…[et al.]. Xiao-Qing-Long-Tang Maintains Cardiac Function during Heart Failure with Reduced Ejection Fraction in Salt-Sensitive Rats by Regulating the Imbalance of Cardiac Sympathetic Innervation. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1158523
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Zhaoyu& Wang, Yongcheng& Jiang, Yuehua& Ma, Dufang& Jiang, Ping& Zhou, Guofeng…[et al.]. Xiao-Qing-Long-Tang Maintains Cardiac Function during Heart Failure with Reduced Ejection Fraction in Salt-Sensitive Rats by Regulating the Imbalance of Cardiac Sympathetic Innervation. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1158523
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1158523
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر