Shikonin Inhibits Der p 2-Induced Cytokine and Chemokine Expression in Dendritic Cells in Patients with Atopic Dermatitis
المؤلفون المشاركون
Chiang, Wen-Dee
Yen, Chung-Yang
Liu, Shang-Yong
Yu, Sheng-Jie
Hsieh, Ching-Liang
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-08-02
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Atopic dermatitis (AD) is a common inflammatory skin disorder.
Shikonin, the active component of Lithospermum erythrorhizon extract, exhibits anti-inflammatory effects.
The objective of the present study was to investigate the effect of shikonin on proinflammatory cytokines and chemokine in patients with AD.
Ten patients with AD who were allergic to house dust mite (HDM) and seven healthy controls were recruited in this study.
Peripheral blood mononuclear cells were isolated, and CD14+ cells were further selected and differentiated to dendritic cells.
Dendritic cells stimulated using Der p 2, the major HDM allergen, were cotreated with shikonin for 24 hours, and dexamethasone was used as a control.
Culture supernatants were collected, and proinflammatory cytokine and chemokine concentrations were analyzed using a multiplex assay system.
Shikonin significantly inhibited Der p 2-induced expression of interleukin (IL)-6, IL-9, and IL-17A; monocyte chemoattractant protein (MCP)-1; macrophage inflammatory protein (MIP)-1α; MIP-1β; and Chemokine (C-C motif) ligand 5 (RANTES).
The inhibitory effects of shikonin on IL-9, MIP-1β, and RANTES expression were stronger than those of dexamethasone.
Therefore, Shikonin can be considered a promising drug for AD treatment because it inhibits different inflammatory cytokines expression.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yen, Chung-Yang& Chiang, Wen-Dee& Liu, Shang-Yong& Yu, Sheng-Jie& Hsieh, Ching-Liang. 2020. Shikonin Inhibits Der p 2-Induced Cytokine and Chemokine Expression in Dendritic Cells in Patients with Atopic Dermatitis. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1158546
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yen, Chung-Yang…[et al.]. Shikonin Inhibits Der p 2-Induced Cytokine and Chemokine Expression in Dendritic Cells in Patients with Atopic Dermatitis. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1158546
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yen, Chung-Yang& Chiang, Wen-Dee& Liu, Shang-Yong& Yu, Sheng-Jie& Hsieh, Ching-Liang. Shikonin Inhibits Der p 2-Induced Cytokine and Chemokine Expression in Dendritic Cells in Patients with Atopic Dermatitis. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1158546
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1158546
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر