Resveratrol Treatment Is Associated with Lipid Regulation and Inhibition of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2)‎ in Rabbits Fed a High-Fat Diet

المؤلفون المشاركون

Xu, Lei
Wang, Renjie
Liu, Hongyu
Wang, Jiaoqi
Mang, Jing
Xu, Zhongxin

المصدر

Evidence-Based Complementary and Alternative Medicine

العدد

المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-8، 8ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2020-05-20

دولة النشر

مصر

عدد الصفحات

8

التخصصات الرئيسية

الطب البشري

الملخص EN

The effects of resveratrol on various conditions have been widely studied previously.

This paper aimed to investigate the influence of resveratrol on atherosclerosis (AS).

Twenty-four New Zealand male rabbits were randomly and equally assigned to the normal diet group (NDG), fat diet group (FDG), and fat diet with resveratrol group (80 mg/kg/d, RFG).

Biochemical indicators from blood samples were analyzed at baseline and 3 months to investigate the effects of resveratrol on blood lipid, lipoprotein-associated phospholipase A2 (Lp-PLA2), liver, and renal function.

The indicators including alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatinine (CREA), triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and Lp-PLA2.

At 3 months, arteries were stained with hematoxylin and eosin to study the influence of resveratrol on the aortic intima, smooth muscle layer, and the intima/media ratio.

Comparisons of weight, ALT, AST, CREA, TG, TC, HDL-C, LDL-C, and Lp-PLA2 among the three groups showed no significant difference at baseline.

However, at the end of 3 months, significant differences were observed in AST, CREA, TC, HDL-C, LDL-C, and Lp-PLA2 between the three groups (P<0.05).

In pairwise comparison, CREA, TC, LDL-C, and Lp-PLA2 had significant differences between any two groups (P<0.05).

In addition, there were significant differences in the AST and HDL-C levels between RFG and NDG groups (P<0.05).

Meanwhile, the HDL-C levels were also significantly different between the FDG and NDG groups (P<0.01).

The histologic analysis also showed that the thickness of the aortic intima and the ratio of the intima and aortic tunica media (P<0.05) significantly decreased in RFG compared to FDG.

Resveratrol may have an antiatherosclerosis effect on a rabbit model of AS.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Xu, Lei& Wang, Renjie& Liu, Hongyu& Wang, Jiaoqi& Mang, Jing& Xu, Zhongxin. 2020. Resveratrol Treatment Is Associated with Lipid Regulation and Inhibition of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) in Rabbits Fed a High-Fat Diet. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1158653

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Xu, Lei…[et al.]. Resveratrol Treatment Is Associated with Lipid Regulation and Inhibition of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) in Rabbits Fed a High-Fat Diet. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1158653

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Xu, Lei& Wang, Renjie& Liu, Hongyu& Wang, Jiaoqi& Mang, Jing& Xu, Zhongxin. Resveratrol Treatment Is Associated with Lipid Regulation and Inhibition of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) in Rabbits Fed a High-Fat Diet. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1158653

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1158653