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Resveratrol Treatment Is Associated with Lipid Regulation and Inhibition of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) in Rabbits Fed a High-Fat Diet
المؤلفون المشاركون
Xu, Lei
Wang, Renjie
Liu, Hongyu
Wang, Jiaoqi
Mang, Jing
Xu, Zhongxin
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-05-20
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
The effects of resveratrol on various conditions have been widely studied previously.
This paper aimed to investigate the influence of resveratrol on atherosclerosis (AS).
Twenty-four New Zealand male rabbits were randomly and equally assigned to the normal diet group (NDG), fat diet group (FDG), and fat diet with resveratrol group (80 mg/kg/d, RFG).
Biochemical indicators from blood samples were analyzed at baseline and 3 months to investigate the effects of resveratrol on blood lipid, lipoprotein-associated phospholipase A2 (Lp-PLA2), liver, and renal function.
The indicators including alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatinine (CREA), triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and Lp-PLA2.
At 3 months, arteries were stained with hematoxylin and eosin to study the influence of resveratrol on the aortic intima, smooth muscle layer, and the intima/media ratio.
Comparisons of weight, ALT, AST, CREA, TG, TC, HDL-C, LDL-C, and Lp-PLA2 among the three groups showed no significant difference at baseline.
However, at the end of 3 months, significant differences were observed in AST, CREA, TC, HDL-C, LDL-C, and Lp-PLA2 between the three groups (P<0.05).
In pairwise comparison, CREA, TC, LDL-C, and Lp-PLA2 had significant differences between any two groups (P<0.05).
In addition, there were significant differences in the AST and HDL-C levels between RFG and NDG groups (P<0.05).
Meanwhile, the HDL-C levels were also significantly different between the FDG and NDG groups (P<0.01).
The histologic analysis also showed that the thickness of the aortic intima and the ratio of the intima and aortic tunica media (P<0.05) significantly decreased in RFG compared to FDG.
Resveratrol may have an antiatherosclerosis effect on a rabbit model of AS.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xu, Lei& Wang, Renjie& Liu, Hongyu& Wang, Jiaoqi& Mang, Jing& Xu, Zhongxin. 2020. Resveratrol Treatment Is Associated with Lipid Regulation and Inhibition of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) in Rabbits Fed a High-Fat Diet. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1158653
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xu, Lei…[et al.]. Resveratrol Treatment Is Associated with Lipid Regulation and Inhibition of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) in Rabbits Fed a High-Fat Diet. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1158653
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xu, Lei& Wang, Renjie& Liu, Hongyu& Wang, Jiaoqi& Mang, Jing& Xu, Zhongxin. Resveratrol Treatment Is Associated with Lipid Regulation and Inhibition of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) in Rabbits Fed a High-Fat Diet. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1158653
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1158653
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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