Effect of Coptis chinensis on Biofilm Formation and Antibiotic Susceptibility in Mycobacterium abscessus
المؤلفون المشاركون
Li, Tsai-Chung
Tseng, Cheng-Yin
Lin, Ching-Ting
Sun, Mao-Feng
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-11-10
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Mycobacterium abscessus infections are notoriously difficult to be treated and newer treatment options are required.
Coptis chinensis (C.
chinensis) and its main compound berberine are frequently used to treat bacterial and viral infections.
In this study, the susceptibility of M.
abscessus to C.
chinensis extract and berberine was assessed by minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) evaluation.
The effects of C.
chinensis and berberine on biofilm formation and antibiotic susceptibility in M.
abscessus were observed.
C.
chinensis at concentrations of MIC (1.5 mg/mL) and 2 × MIC (3.0 mg/mL) and berberine at ½ × MIC (0.125 mg/mL) demonstrated a strong inhibition of biofilm formation.
Concentration of C.
chinensis at ½ × MIC resulted in a significant reduction in MICs of trimethoprim/sulfamethoxazole (TMP/SXT), clarithromycin (CLA), and linezolid (LZD).
Similarly, ½ × MIC berberine had a significant effect on the MIC reductions of nine antibiotics including TMP/SXT, CLA, and LZD.
Notably, the resistance level MIC of LZD against M.
abscessus was reversed to a susceptible level by treatment with either C.
chinensis or berberine.
Therefore, C.
chinensis and berberine have the potential to produce a synergistic antimycobacterial effect, reduce biofilm formation, and decrease antibacterial resistance to LZD in M.
abscessus.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tseng, Cheng-Yin& Sun, Mao-Feng& Li, Tsai-Chung& Lin, Ching-Ting. 2020. Effect of Coptis chinensis on Biofilm Formation and Antibiotic Susceptibility in Mycobacterium abscessus. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1158697
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tseng, Cheng-Yin…[et al.]. Effect of Coptis chinensis on Biofilm Formation and Antibiotic Susceptibility in Mycobacterium abscessus. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1158697
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tseng, Cheng-Yin& Sun, Mao-Feng& Li, Tsai-Chung& Lin, Ching-Ting. Effect of Coptis chinensis on Biofilm Formation and Antibiotic Susceptibility in Mycobacterium abscessus. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1158697
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1158697
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر