In Vitro and In Vivo Anti-Inflammatory Activities of Benjakul: A Potential Medicinal Product from Thai Traditional Medicine

المؤلفون المشاركون

Itharat, Arunporn
Ooraikul, Buncha
Kuropakornpong, Pranporn
Panthong, Sumalee
Sireeratawong, Seewaboon

المصدر

Evidence-Based Complementary and Alternative Medicine

العدد

المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-8، 8ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2020-07-14

دولة النشر

مصر

عدد الصفحات

8

التخصصات الرئيسية

الطب البشري

الملخص EN

Benjakul (BJK) is a Thai traditional remedy consisting of five plants: Piper chaba Hunt., Piper sarmentosum Roxb., Piper interruptum Opiz., Plumbago indica Linn., and Zingiber officinale Roscoe.

It is used as a first-line drug to balance patient’s symptoms before other treatments.

BJK ethanolic extract has been reported to show anti-inflammatory activity through various mediators, e.g., nitric oxide, TNF-α, IL-1β, and IL-6.

Therefore, BJK could serve as a potential novel anti-inflammatory herbal medicine.

However, studies on prostaglandin E2 (PGE2), one of the key mediators in acute inflammation, and anti-inflammation in animal models (in vivo) have not been done.

This study investigated the anti-inflammatory activity of BJK extract and some of its chemical compounds against PGE2 production in murine macrophage (RAW 264.7) cell line and two in vivo models of anti-inflammatory studies.

Ethanolic extract of BJK (BJK[E]) showed high inhibitory activity against PGE2 production with an IC50 value of 5.82 ± 0.10 μg/mL but its water extract (BJK[W]) was inactive.

Two chemicals from BJK[E], i.e., plumbagin and myristicin, which served as biological markers, showed strong activity with IC50 values of 0.08 ± 0.01 and 1.80 ± 0.06 μg/mL, respectively.

BJK[E] was administered both topically and orally to rats inhibited with inflammation induced by ethyl phenylpropiolate (rat ear edema model) and carrageenan (hind paw edema model).

Moreover, the biological activity of BJK extract did not reduce after six-month storage under accelerated condition (40°C, 75% RH).

This indicated its stability and a 24-month shelf-life under normal condition.

These results supported not only the use of BJK in Thai traditional medicine but also the possibility of further development of phytopharmaceutical products from BJK.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Kuropakornpong, Pranporn& Itharat, Arunporn& Panthong, Sumalee& Sireeratawong, Seewaboon& Ooraikul, Buncha. 2020. In Vitro and In Vivo Anti-Inflammatory Activities of Benjakul: A Potential Medicinal Product from Thai Traditional Medicine. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1158709

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Kuropakornpong, Pranporn…[et al.]. In Vitro and In Vivo Anti-Inflammatory Activities of Benjakul: A Potential Medicinal Product from Thai Traditional Medicine. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1158709

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Kuropakornpong, Pranporn& Itharat, Arunporn& Panthong, Sumalee& Sireeratawong, Seewaboon& Ooraikul, Buncha. In Vitro and In Vivo Anti-Inflammatory Activities of Benjakul: A Potential Medicinal Product from Thai Traditional Medicine. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1158709

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1158709