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Integrated Analysis of the Mechanisms of Da-Chai-Hu Decoction in Type 2 Diabetes Mellitus by a Network Pharmacology Approach
المؤلفون المشاركون
Cheng, Fafeng
Wang, Xueqian
Ren, Beida
Ji, Wenting
Tan, Ling
Xiong, Yiliang
Mu, Jie
Pei, Yuying
Wang, Qingguo
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-21، 21ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-04-28
دولة النشر
مصر
عدد الصفحات
21
التخصصات الرئيسية
الملخص EN
Background.
The incidence of type 2 diabetes mellitus (T2DM) has increased year by year, which not only seriously affects people’s quality of life, but also imposes a heavy economic burden on the family, society, and country.
Currently, the pathogenesis, diagnosis, and treatment of T2DM are still unclear.
Therefore, exploration of a precise multitarget treatment strategy is urgent.
Here, we attempt to screen out the active components, effective targets, and functional pathways of therapeutic drugs through network pharmacology with taking advantages of traditional Chinese medicine (TCM) formulas for multitarget holistic treatment of diseases to clarify the potential therapeutic mechanism of TCM formulas and provide a systematic and clear thought for T2DM treatment.
Methods.
First, we screened the active components of Da-Chai-Hu Decoction (DCHD) by absorption, distribution, metabolism, excretion, and toxicity (ADME/T) calculation.
Second, we predicted and screened the active components of DCHD and its therapeutic targets for T2DM relying on the Traditional Chinese Medicine Systems Pharmacology Analysis Platform (TCMSP database) and Text Mining Tool (GoPubMed database), while using the Database for Annotation, Visualization, and Integrated Discovery (DAVID) to obtain T2DM targets.
Third, we constructed a network of the active component-target, target-pathway of DCHD using Cytoscape software (http://cytoscape.org/,ver.3.5.1) and then analyzed gene function, related biological processes, and signal pathways through the DAVID database.
Results.
We screened 77 active components from 1278 DCHD components and 116 effective targets from 253 ones.
After matching the targets of T2DM, we obtained 38 important targets and 7 core targets were selected through further analysis.
Through enrichment analysis, we found that these important targets were mainly involved in many biological processes such as oxidative stress, inflammatory reaction, and apoptosis.
After analyzing the relevant pathways, the synthetic pathway for the treatment of T2DM was obtained, which provided a diagnosis-treatment idea for DCHD in the treatment of T2DM.
Conclusions.
This article reveals the mechanism of DCHD in the treatment of T2DM related to inflammatory response and apoptosis through network pharmacology, which lays a foundation for further elucidation of drugs effective targets.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ren, Beida& Tan, Ling& Xiong, Yiliang& Ji, Wenting& Mu, Jie& Pei, Yuying…[et al.]. 2020. Integrated Analysis of the Mechanisms of Da-Chai-Hu Decoction in Type 2 Diabetes Mellitus by a Network Pharmacology Approach. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-21.
https://search.emarefa.net/detail/BIM-1158713
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ren, Beida…[et al.]. Integrated Analysis of the Mechanisms of Da-Chai-Hu Decoction in Type 2 Diabetes Mellitus by a Network Pharmacology Approach. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-21.
https://search.emarefa.net/detail/BIM-1158713
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ren, Beida& Tan, Ling& Xiong, Yiliang& Ji, Wenting& Mu, Jie& Pei, Yuying…[et al.]. Integrated Analysis of the Mechanisms of Da-Chai-Hu Decoction in Type 2 Diabetes Mellitus by a Network Pharmacology Approach. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-21.
https://search.emarefa.net/detail/BIM-1158713
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1158713
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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