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Geospatial Investigation of Nigerian Honey and Detection of Anti-Enteric Biomarker
المؤلفون المشاركون
Akinduti, P. Akinniyi
Ejilude, Oluwaseun
Olugbuyiro, Joseph
Adewale, Adeyemi G.
Onagbesan, Okanlawon
Oluwadun, Afolabi
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-04-29
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Geospatial mapping and antibacterial biomarkers were investigated in Nigerian honey used for therapeutic purposes in several communities affected with prevalent antibiotic-resistant enteric bacilli.
Randomly collected enteric bacilli from faecal samples were biotyped and phenotypically assayed for antibiotic resistance and profiled for R plasmids.
R plasmid molecular weight and multiantibiotic resistance index (MARI) relatedness were evaluated for resistance among phylogroups.
Honey cidal activity, time kill kinetics, and bioactive markers were determined and analysed for geospatial distribution.
More than 30% enteric biotypes were resistant to cotrimoxazole, ciprofloxacin, and tetracycline at MIC ≥16 μg/ml (P=0.004).
Two unrelated cluster complexes with diverse antibiotic resistance indices expressed high molecular weight plasmid (14.17 kbp) with 0.73 MARI to two classes of antibiotics.
Among the resistant bacilli, only 24.3% (MIC90 500 mg/mL) and 8.1% (MBC90 1000 mg/mL) were susceptible to honey with evidence of 14.85% and 5.94% significant viable reduction at 2 × MIC to less than 2.50 Log10 CFU/mL (P<0.05).
Only alkaloids significantly regressed (P=0.028) with susceptibility of resistant bacilli significantly correlate with bacteria inhibition (r = 0.534, P=0.049) at optimal cutoff limit of 0.32 mg/ml.
Antibacterial honey with significant alkaloid biomarkers was detected at 3°10′0–3°30′0E and 6°30′0–7°30′0N of Southwest Nigeria.
Spatial mapping evidently indicated variation in honey physicochemical and bioactive compounds and identified geographical locations suitable for production of anti-enteric honey rich in alkaloids marker required for prevention and treatment of resistant enteric bacilli infections.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Akinduti, P. Akinniyi& Ejilude, Oluwaseun& Olugbuyiro, Joseph& Adewale, Adeyemi G.& Onagbesan, Okanlawon& Oluwadun, Afolabi. 2020. Geospatial Investigation of Nigerian Honey and Detection of Anti-Enteric Biomarker. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1158752
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Akinduti, P. Akinniyi…[et al.]. Geospatial Investigation of Nigerian Honey and Detection of Anti-Enteric Biomarker. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1158752
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Akinduti, P. Akinniyi& Ejilude, Oluwaseun& Olugbuyiro, Joseph& Adewale, Adeyemi G.& Onagbesan, Okanlawon& Oluwadun, Afolabi. Geospatial Investigation of Nigerian Honey and Detection of Anti-Enteric Biomarker. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1158752
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1158752
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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