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A Novel Analysis via Micro-CT Imaging Indicates That Chemically Modified Tetracycline-3 (CMT-3) Inhibits Tooth Relapse after Orthodontic Movement: A Pilot Experimental Study
المؤلفون المشاركون
Bentes de Azevedo, Ricardo
Falcão, Denise Pinheiro
de Amorim, Rivadávio Fernandes Batista
Vieira, Giovanni Modesto
Queiroz, Sormani Bento Fernandes de
Lima, Valthierre Nunes de
Tiziane, Valdenize
Moreno, Heitor
المصدر
International Journal of Dentistry
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-04-01
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Objective.
To evaluate the effect of chemically modified tetracycline-3 (CMT-3) and simvastatin on tooth relapse after orthodontic movement in rats using a novel analysis method employing high-resolution micro-CT (Micro-CT) images.
In addition, the correlation between bone density and orthodontic relapse was also evaluated for each experimental group.
Methods.
Forty adult male Wistar rats had stainless steel springs installed on their left upper first molars in order to generate tooth movement for 18 days.
After this initial period, the animals were divided into three groups: (1) 30 mg/kg of CMT-3; (2) 5 mg/kg of simvastatin; and (3) 0.5% carboxymethylcellulose, and each group was treated for 20 days.
Micro-CT images were analyzed (conventional method and 3D reconstruction) on the 7th and 18th days following spring fixation and finally, 20 days after treatment either with CMT-3 or simvastatin (38th day).
Bone mineral density (BMD) of the mesial and distal roots of the upper first molar was also analyzed.
Results.
The difference was statistically significant between the groups as to recurrence (p=0.048), and the post hoc test identified the value of p=0.007 between the control group and the CMT-3 group.
Simvastatin was not able to inhibit tooth relapse.
The bone mineral densities of both the mesial and distal roots were different between the three groups, after the 20th day of drug use (p=0001 and p<0001).
Conclusion.
Our findings support the initial evidence that CMT-3 is able to prevent relapse after tooth movement.
Future trials in humans should evaluate such treatment as a promising approach to preventing this common phenomenon.
Clinical Relevance.
Considering the results obtained, CMT-3 can be used to avoid relapse after tooth movement.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Vieira, Giovanni Modesto& Falcão, Denise Pinheiro& Queiroz, Sormani Bento Fernandes de& Lima, Valthierre Nunes de& Bentes de Azevedo, Ricardo& Tiziane, Valdenize…[et al.]. 2019. A Novel Analysis via Micro-CT Imaging Indicates That Chemically Modified Tetracycline-3 (CMT-3) Inhibits Tooth Relapse after Orthodontic Movement: A Pilot Experimental Study. International Journal of Dentistry،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1158966
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Vieira, Giovanni Modesto…[et al.]. A Novel Analysis via Micro-CT Imaging Indicates That Chemically Modified Tetracycline-3 (CMT-3) Inhibits Tooth Relapse after Orthodontic Movement: A Pilot Experimental Study. International Journal of Dentistry No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1158966
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Vieira, Giovanni Modesto& Falcão, Denise Pinheiro& Queiroz, Sormani Bento Fernandes de& Lima, Valthierre Nunes de& Bentes de Azevedo, Ricardo& Tiziane, Valdenize…[et al.]. A Novel Analysis via Micro-CT Imaging Indicates That Chemically Modified Tetracycline-3 (CMT-3) Inhibits Tooth Relapse after Orthodontic Movement: A Pilot Experimental Study. International Journal of Dentistry. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1158966
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1158966
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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