Effect of Prehospital Epinephrine on Outcomes of Out-of-Hospital Cardiac Arrest: A Bayesian Network Approach
المؤلفون المشاركون
Choi, Han Joo
Moon, Hyung Jun
Kim, Gi Woon
Kim, Yu Jin
Kim, Joonghee
Han, Sangsoo
المصدر
Emergency Medicine International
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-08-01
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
The benefit of prehospital epinephrine in out-of-hospital cardiac arrest (OHCA) was shown in a recent large placebo-controlled trial.
However, placebo-controlled studies cannot identify the nonpharmacologic influences on concurrent or downstream events that might modify the main effect positively or negatively.
We sought to identify the real-world effect of epinephrine from a clinical registry using Bayesian network with time-sequence constraints.
Methods.
We analyzed a prospective regional registry of OHCA where a prehospital advanced life support (ALS) protocol named “Smart ALS (SALS)” was gradually implemented from July 2015 to December 2016.
Using Bayesian network, a causal structure was estimated.
The effect of epinephrine and SALS program was modelled based on the structure using extended Cox-regression and logistic regression, respectively.
Results.
Among 4324 patients, SALS was applied to 2351 (54.4%) and epinephrine was administered in 1644 (38.0%).
Epinephrine was associated with faster ROSC rate in nonshockable rhythm (HR: 2.02, 6.94, and 7.43; 95% CI: 1.08–3.78, 4.15–11.61, and 2.92–18.91, respectively, for 1–10, 11–20, and >20 minutes) while it was associated with slower rate up to 20 minutes in shockable rhythm (HR: 0.40, 0.50, and 2.20; 95% CI: 0.21–0.76, 0.32–0.77, and 0.76–6.33).
SALS was associated with increased prehospital ROSC and neurologic recovery in noncardiac etiology (HR: 5.36 and 2.05; 95% CI: 3.48–8.24 and 1.40–3.01, respectively, for nonshockable and shockable rhythm).
Conclusions.
Epinephrine was associated with faster ROSC rate in nonshockable rhythm but slower rate in shockable rhythm up to 20 minutes.
SALS was associated with improved prehospital ROSC and neurologic recovery in noncardiac etiology.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kim, Joonghee& Kim, Yu Jin& Han, Sangsoo& Choi, Han Joo& Moon, Hyung Jun& Kim, Gi Woon. 2020. Effect of Prehospital Epinephrine on Outcomes of Out-of-Hospital Cardiac Arrest: A Bayesian Network Approach. Emergency Medicine International،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1159140
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kim, Joonghee…[et al.]. Effect of Prehospital Epinephrine on Outcomes of Out-of-Hospital Cardiac Arrest: A Bayesian Network Approach. Emergency Medicine International No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1159140
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kim, Joonghee& Kim, Yu Jin& Han, Sangsoo& Choi, Han Joo& Moon, Hyung Jun& Kim, Gi Woon. Effect of Prehospital Epinephrine on Outcomes of Out-of-Hospital Cardiac Arrest: A Bayesian Network Approach. Emergency Medicine International. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1159140
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1159140
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر