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The Effect of a Modified Constant Flow Insufflation of Oxygen during Cardiopulmonary Resuscitation in a Rat Model of Respiratory Cardiac Arrest on Arterial Oxygenation, Alveolar Barotrauma, and Brain Tissue Injury
المؤلفون المشاركون
Choi, Hyukjoong
Lee, Sanghyun
Lim, Tae Ho
Lee, Yoonjae
Kim, Changsun
Park, Jinkyu
Hwang, Sejin
المصدر
Emergency Medicine International
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-03-31
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Aim.
Intermittent positive pressure ventilation (IPPV) can adversely affect cardiopulmonary resuscitation outcomes by increasing the intrathoracic pressure.
Continuous flow insufflation of oxygen (CFIO) has been investigated as a potential alternative, but evidence supporting its superiority over intermittent positive pressure ventilation in cases of cardiac arrest is scant.
The aim of the current study was to compare the effects of continuous flow insufflation of oxygen using a one-way valve during cardiopulmonary-resuscitation with intermittent positive pressure ventilation in a rat model of respiratory arrest.
Methods.
Male Sprague-Dawley rats weighing 400∼450 g (from minimum to maximum) were randomly assigned to either a sham, IPPV, or CFIO group (n = 10 per group).
Respiratory arrest was induced by blocking the endotracheal tube.
Arterial blood gas analysis was performed during cardiopulmonary resuscitation to compare the oxygenation levels.
Tissues were then harvested to compare the degrees of pulmonary barotrauma and ischemic brain injury.
Results.
Return of spontaneous circulation was observed in 6/10 rats in the IPPV group and 5/10 in the CFIO group.
During cardiopulmonary resuscitation, the mean PaO2 was significantly higher in the CFIO group (83.10 mmHg) than in the IPPV group (56.10 mmHg).
Lung biopsy revealed more inflammatory cells and marked thickening of the alveolar wall in the IPPV group; the group also exhibited a higher frequency of neuroglial cells and apoptotic bodies of pyramidal cells, resulting from ischemic injury.
Conclusion.
In a rat model of respiratory arrest, CFIO using a one-way valve resulted in a greater level of oxygenation and less lung and brain injuries than with IPPV.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lee, Yoonjae& Lee, Sanghyun& Choi, Hyukjoong& Park, Jinkyu& Hwang, Sejin& Lim, Tae Ho…[et al.]. 2020. The Effect of a Modified Constant Flow Insufflation of Oxygen during Cardiopulmonary Resuscitation in a Rat Model of Respiratory Cardiac Arrest on Arterial Oxygenation, Alveolar Barotrauma, and Brain Tissue Injury. Emergency Medicine International،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1159168
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lee, Yoonjae…[et al.]. The Effect of a Modified Constant Flow Insufflation of Oxygen during Cardiopulmonary Resuscitation in a Rat Model of Respiratory Cardiac Arrest on Arterial Oxygenation, Alveolar Barotrauma, and Brain Tissue Injury. Emergency Medicine International No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1159168
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lee, Yoonjae& Lee, Sanghyun& Choi, Hyukjoong& Park, Jinkyu& Hwang, Sejin& Lim, Tae Ho…[et al.]. The Effect of a Modified Constant Flow Insufflation of Oxygen during Cardiopulmonary Resuscitation in a Rat Model of Respiratory Cardiac Arrest on Arterial Oxygenation, Alveolar Barotrauma, and Brain Tissue Injury. Emergency Medicine International. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1159168
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1159168
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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