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The Polymorphisms at PRSS1-PRSS2 and MORC4 Loci and the Risk of Post-ERCP Pancreatitis
المؤلفون المشاركون
Angsuwatcharakon, Phonthep
Sodsai, Pimpayao
Hirankarn, Nattiya
Rerknimitr, Rungsun
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-4، 4ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-11-04
دولة النشر
مصر
عدد الصفحات
4
التخصصات الرئيسية
الملخص EN
Background and Aim.
The risks of post-ERCP pancreatitis (PEP) are identified as patient- and procedure-related factors.
However, the genetic contribution for PEP is still unclear.
Recent data show that the polymorphisms of PRSS1-PRSS2 (rs10273639) and MORC4 (rs12688220) are associated with recurrent acute pancreatitis and chronic pancreatitis.
We aim to evaluate the association between these polymorphisms and post-ERCP pancreatitis in order to improve better prognosis and better care for these patients.
Methods.
This is a retrospective, case-control study which includes 49 cases and 97 controls that are age-, procedure-, and risk of PEP-matched with the cases in 1 : 2 fashion.
The PEP was diagnosed and graded for severity according to the standard consensus, and the risk factors of PEP were identified according to the ESGE guideline.
Polymorphisms at rs10273639 and rs12688220 were evaluated by TaqMan technique and were identified in 133 (40 cases and 93 controls) and 146 patients, respectively.
Results.
The demographic data between 2 groups are not significantly different.
The genotype frequencies of PRSS1-PRSS2 (TT, TC, and CC) are 26, 13, and 1 vs.
67, 25, and 1 in cases and controls, respectively (p=0.642).
The genotype frequencies of MORC4 in female (TT, TC, and CC) are 8, 23, and 5 vs.
12, 26, and 21 in cases and controls, respectively (p=0.071).
The genotype frequencies of MORC4 in male (T and C) are 5 and 8 vs.
21 and 17 in cases and controls, respectively (p=0.468).
The allelic frequencies of MORC4 in combination of both genders (T, C) are 44 and 41 vs.
71 and 84 in cases and control, respectively (p=0.431).
In PEP cases, the allelic frequencies of PRSS1-PRSS2 (T and C) are 59 and 13 vs.
6 and 2 in mild and moderate/severe cases, respectively (p=0.633).
The allelic frequencies of MORC4 (T and C) are 38 and 39 vs.
4 and 4 in mild and moderate/severe cases, respectively (p=0.972).
Conclusion.
Polymorphisms at PRSS1-PRSS2 and MORC4 are not associated with the risk or severity of post-ERCP pancreatitis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Angsuwatcharakon, Phonthep& Sodsai, Pimpayao& Rerknimitr, Rungsun& Hirankarn, Nattiya. 2018. The Polymorphisms at PRSS1-PRSS2 and MORC4 Loci and the Risk of Post-ERCP Pancreatitis. Gastroenterology Research and Practice،Vol. 2018, no. 2018, pp.1-4.
https://search.emarefa.net/detail/BIM-1159218
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Angsuwatcharakon, Phonthep…[et al.]. The Polymorphisms at PRSS1-PRSS2 and MORC4 Loci and the Risk of Post-ERCP Pancreatitis. Gastroenterology Research and Practice No. 2018 (2018), pp.1-4.
https://search.emarefa.net/detail/BIM-1159218
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Angsuwatcharakon, Phonthep& Sodsai, Pimpayao& Rerknimitr, Rungsun& Hirankarn, Nattiya. The Polymorphisms at PRSS1-PRSS2 and MORC4 Loci and the Risk of Post-ERCP Pancreatitis. Gastroenterology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-4.
https://search.emarefa.net/detail/BIM-1159218
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1159218
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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