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Etiology and Clinical Presentation of Disorders of Sex Development in Kenyan Children and Adolescents
المؤلفون المشاركون
Laigong, Paul
Amolo, Prisca
Omar, Anjumanara
Drop, Stenvert
المصدر
International Journal of Endocrinology
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-12-01
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Objective.
The purpose of this study was to describe baseline data on etiological, clinical, laboratory, and management strategies in Kenyan children and adolescents with Disorders of Sex Development (DSD).
Methods.
This retrospective study included patients diagnosed with DSD who presented at ages 0–19 years from January 2008 to December 2015 at the Kenyatta National (KNH) and Gertrude’s Children’s (GCH) Hospitals.
After conducting a search in the data registry, a structured data collection sheet was used for collection of demographic and clinical data.
Data analysis involved description of the frequency of occurrence of various variables, such as etiologic diagnoses and patient characteristics.
Results.
Data from the records of 71 children and adolescents were reviewed at KNH (n = 57, 80.3%) and GCH (n = 14, 19.7%).
The mean age at the time of diagnosis was 2.7 years with a median of 3 months.
Thirty-nine (54.9%) children had karyotype testing done.
The median age (IQR) of children with reported karyotypes and those without was 3.3 years (1.3–8.9) and 8.3 years (3.6–12.1), respectively (p=0.021).
Based on karyotype analysis, 19 (48.7%) of karyotyped children had 46,XY DSD and 18 (46.2%) had 46,XX DSD.
There were two (5.1%) children with sex chromosome DSD.
Among the 71 patients, the most common presumed causes of DSD were ovotesticular DSD (14.1%) and CAH (11.3%).
Majority (95.7%) of the patients presented with symptoms of DSD at birth.
The most common presenting symptom was ambiguous genitalia, which was present in 66 (93.0%) patients either in isolation or in association with other symptoms.
An ambiguous genitalia was initially observed by the patient’s mother in 51.6% of 62 cases despite the high rate (84.7%) of delivery in hospital.
Seventeen (23.9%) of the cases had a gender reassignment at final diagnosis.
A psychologist/psychiatrist or counselor was involved in the management of 23.9% of the patients.
Conclusion.
The commonest presumed cause of DSD was ovotesticular DSD in contrast to western studies, which found CAH to be more common.
Investigation of DSD cases is expensive and needs to be supported.
We would have liked to do molecular genetic analysis outside the country but financial challenges made it impossible.
A network for detailed diagnostics in resource-limited countries would be highly desirable.
There is a need to train health care workers and medical students for early diagnosis.
Psychological evaluation should be carried out for all patients at diagnosis and support given for families.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Amolo, Prisca& Laigong, Paul& Omar, Anjumanara& Drop, Stenvert. 2019. Etiology and Clinical Presentation of Disorders of Sex Development in Kenyan Children and Adolescents. International Journal of Endocrinology،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1159434
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Amolo, Prisca…[et al.]. Etiology and Clinical Presentation of Disorders of Sex Development in Kenyan Children and Adolescents. International Journal of Endocrinology No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1159434
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Amolo, Prisca& Laigong, Paul& Omar, Anjumanara& Drop, Stenvert. Etiology and Clinical Presentation of Disorders of Sex Development in Kenyan Children and Adolescents. International Journal of Endocrinology. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1159434
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1159434
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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