The Immunoexpression of Glucocorticoid Receptors in Breast Carcinomas, Lactational Change, and Normal Breast Epithelium and Its Possible Role in Mammary Carcinogenesis
المؤلفون المشاركون
Alyusuf, Raja
Wazir, Javed Fayyaz
Brahmi, Urmil Prabha
Fakhro, Abdul Rahman
Bakhiet, Moiz
المصدر
International Journal of Breast Cancer
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-11-19
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
The role of estrogen and progesterone receptors in breast cancer biology is well established.
In contrast, other steroid hormones are less well studied.
Glucocorticoids (GCs) are known to play a role in mammary development and differentiation; thus, it is of interest to attempt to delineate their immunoexpression across a spectrum of mammary epithelia.
Aim.
To delineate the distribution pattern of glucocorticoid receptors (GRs) in malignant versus nonmalignant epithelium with particular emphasis on lactational epithelium.
Materials and Methods.
Immunohistochemistry (IHC) for GRs was performed on archival formalin-fixed paraffin-embedded tissue blocks of 96 cases comprising 52 invasive carcinomas, 21 cases with lactational change, and 23 cases showing normal mammary tissue histology.
Results.
Results reveal an overexpression of GRs in mammary malignant epithelium as compared to both normal and lactational groups individually and combined.
GR overexpression is significantly more pronounced in HER-2-negative cancers.
Discussion.
This is the first study to compare GR expression in human lactating epithelium versus malignant and normal epithelium.
The article discusses the literature related to the pathobiology of GCs in the breast with special emphasis on breast cancer.
Conclusion.
The lactational epithelium did not show overexpression of GR, while GR was overexpressed in mammary NST (ductal) carcinoma, particularly HER-2-negative cancers.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Alyusuf, Raja& Wazir, Javed Fayyaz& Brahmi, Urmil Prabha& Fakhro, Abdul Rahman& Bakhiet, Moiz. 2017. The Immunoexpression of Glucocorticoid Receptors in Breast Carcinomas, Lactational Change, and Normal Breast Epithelium and Its Possible Role in Mammary Carcinogenesis. International Journal of Breast Cancer،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1159533
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Alyusuf, Raja…[et al.]. The Immunoexpression of Glucocorticoid Receptors in Breast Carcinomas, Lactational Change, and Normal Breast Epithelium and Its Possible Role in Mammary Carcinogenesis. International Journal of Breast Cancer No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1159533
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Alyusuf, Raja& Wazir, Javed Fayyaz& Brahmi, Urmil Prabha& Fakhro, Abdul Rahman& Bakhiet, Moiz. The Immunoexpression of Glucocorticoid Receptors in Breast Carcinomas, Lactational Change, and Normal Breast Epithelium and Its Possible Role in Mammary Carcinogenesis. International Journal of Breast Cancer. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1159533
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1159533
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر