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Altered Salivary Alpha-Amylase Secretion in Patients with Ulcerative Colitis
المؤلفون المشاركون
Zhang, Tao
Xu, Zhuoni
Wei, Baoping
Qiu, Yanting
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-05-24
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Purpose.
Patients with ulcerative colitis (UC) frequently present with psychological disturbances as well as dysfunctions of autonomic nervous system (ANS).
Salivary alpha-amylase (sAA) secretion is predominantly controlled by sympathetic nervous activity, while salivary fluid secretion is by parasympathetic nervous activity.
Thus, it is speculated that alterations of salivary secretion may be addressed in UC populations.
Methods.
Thirty-five UC patients as well as 32 age- and sex-matched healthy controls were enrolled.
Saliva samples before and after citric acid stimulation were collected from each participant, and salivary flow rate (SFR) was calculated accordingly.
Western blotting and quantitative PCR were applied to measure the sAA level and sAA gene (AMY1) copy number, respectively.
The psychological disorders, anxiety and depression, were evaluated by the scoring system of Hospital Anxiety and Depression Scale (HADS) for each participant.
Results.
We observed robustly increased prevalence of anxiety (p<0.001) as well as depression (p<0.001) in UC patients relative to controls.
Interestingly, we detected elevated basal (p=0.015) and stimulated (p=0.021) sAA levels in the UC populations compared to controls.
However, no differences were found for basal (p=0.643) or stimulated (p=0.402) SFR between the two study groups.
Besides, AMY1 gene copy number was comparable between UC patients and controls.
Conclusions.
Our results reveal an overactivity of the sympathetic nervous system and a normal activity of the parasympathetic nervous system in the UC population.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xu, Zhuoni& Wei, Baoping& Qiu, Yanting& Zhang, Tao. 2018. Altered Salivary Alpha-Amylase Secretion in Patients with Ulcerative Colitis. Gastroenterology Research and Practice،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1159648
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xu, Zhuoni…[et al.]. Altered Salivary Alpha-Amylase Secretion in Patients with Ulcerative Colitis. Gastroenterology Research and Practice No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1159648
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xu, Zhuoni& Wei, Baoping& Qiu, Yanting& Zhang, Tao. Altered Salivary Alpha-Amylase Secretion in Patients with Ulcerative Colitis. Gastroenterology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1159648
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1159648
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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