Demographic Characteristics, Etiology, and Comorbidities of Patients with Cushing’s Syndrome: A 10-Year Retrospective Study at a Large General Hospital in China
المؤلفون المشاركون
Guo, Xiaopeng
Xing, Bing
Zhou, Jingya
Zhang, Meng
Bai, Xue
Cui, Shengnan
Pang, Cheng
Lu, Lin
Pang, Haiyu
Wang, Yi
المصدر
International Journal of Endocrinology
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-02-19
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Purpose.
To investigate the demographic characteristics, etiology, and comorbidities of Cushing’s syndrome (CS) patients at a large medical center in China.
Methods.
Records on CS patients discharged from 2008 to 2017 were retrieved from the hospital discharge abstract database (DAD) using ICD-10 codes.
Demographic characteristics, etiology, and comorbidity data were analyzed.
Results.
Cushing’s disease (CD) accounted for 63.0% of CS patients, followed by adrenocortical adenoma (ACA) (20.9%), primary bilateral macronodular adrenal hyperplasia (BMAH) (6.2%), ectopic ACTH syndrome (EAS) (5.9%), primary pigmented nodular adrenocortical disease (PPNAD) (1.8%), and adrenocortical carcinoma (ACC) (1.0%).
CD, ACA, ACC, and PPNAD presented marked preponderances in women (4.1 : 1, 10.5 : 1, 4.3 : 1, and 2.3 : 1, respectively), while BMAH (59.8%) and EAS (51.0%) showed slightly higher preponderances in men.
CD patients were younger than ACA and EAS patients (36.1±12.9 years vs.
39.4±12.7 years and 36.1±12.9 years vs.
41.0±15.8, P<0.001); PPNAD patients were the youngest (24.2±10.8 years, P<0.001), and BMAH patients were the oldest (51.3±9.9 years, P<0.001).
Hypertension, diabetes mellitus, osteoporosis without fractures, osteoporotic fractures, dyslipidemia, and fatty liver occurred more frequently in CD patients than in ACA patients (P<0.001 for all).
Osteoporotic fractures were observed more frequently in PPAND than in ACA (26.7% vs.
9.0%, P<0.001) and BMAH (26.7% vs.
4.9%, P<0.001) patients.
EAS patients had more severe and diverse comorbidities, with higher prevalences of hypokalemia (52.0%), diabetes mellitus (61.2%), and osteoporotic fractures (28.6%).
When adjusted for age, male CD patients were associated with hypertension (OR = 2.266, 95% CI: 1.524–3.371, and P<0.001), osteoporotic fractures (OR = 2.274, 95% CI: 1.568–3.298, and P<0.001), fatty liver (OR = 1.435, 95% CI: 1.028–2.003, and P=0.034), and hypokalemia (OR = 1.944, 95% CI: 1.280–2.951, and P=0.002).
Conclusions.
The proposed method efficiently evaluates CS patients’ epidemiological profiles using hospital DADs with ICD-10 codes and thus may enrich the limited epidemiological data and contribute to clinical practice for CS.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhou, Jingya& Zhang, Meng& Bai, Xue& Cui, Shengnan& Pang, Cheng& Lu, Lin…[et al.]. 2019. Demographic Characteristics, Etiology, and Comorbidities of Patients with Cushing’s Syndrome: A 10-Year Retrospective Study at a Large General Hospital in China. International Journal of Endocrinology،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1159697
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhou, Jingya…[et al.]. Demographic Characteristics, Etiology, and Comorbidities of Patients with Cushing’s Syndrome: A 10-Year Retrospective Study at a Large General Hospital in China. International Journal of Endocrinology No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1159697
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhou, Jingya& Zhang, Meng& Bai, Xue& Cui, Shengnan& Pang, Cheng& Lu, Lin…[et al.]. Demographic Characteristics, Etiology, and Comorbidities of Patients with Cushing’s Syndrome: A 10-Year Retrospective Study at a Large General Hospital in China. International Journal of Endocrinology. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1159697
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1159697
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر