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SHMT2 Overexpression Predicts Poor Prognosis in Intrahepatic Cholangiocarcinoma
المؤلفون المشاركون
Ning, Shanglei
Ma, Siquan
Saleh, Abdul Qahar
Guo, Lingyu
Zhao, Zixiao
Chen, Yuxin
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-08-28
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background and Objective.
Serine hydroxymethyltransferase 2 (SHMT2) functions as a key enzyme in serine/glycine biosynthesis and one-carbon metabolism.
Recent studies have shown that SHMT2 participated in tumor growth and progression in a variety of cancer types.
The objective of the present study is to explore the expression of SHMT2 and evaluate its prognostic value in patients with intrahepatic cholangiocarcinoma (iCCA).
Patients and Methods.
We retrospectively investigated the expression of SHMT2 in 100 primary iCCA samples through immunohistochemical (IHC) staining on a tissue array.
Results.
High SHMT2 expression was found in 52 of the 100 specimens.
The results indicated that SHMT2 level was upregulated compared to adjacent nontumor intrahepatic bile duct tissue.
Furthermore, SHMT2 level was closely associated with tumor T stage (P=0.017) and tumor TNM stage (P=0.041) in patients with iCCA, but not with age, gender, tumor size, tumor number, pathological grade, vascular invasion, or N stage.
Moreover, Kaplan-Meier analysis suggested that patients with lower SHMT2 level have longer survival rate than those with high expression (45.8 vs 23.1%, P=0.030).
Additionally, the multivariate analysis model indicated SHMT2 is an independent adverse prognosticator in iCCA.
Conclusion.
High SHMT2 level was correlated with poorer overall survival in patients with iCCA.
SHMT2 was proved to be a powerful and independent prognostic factor and a potential therapeutic target for patients with iCCA.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ning, Shanglei& Ma, Siquan& Saleh, Abdul Qahar& Guo, Lingyu& Zhao, Zixiao& Chen, Yuxin. 2018. SHMT2 Overexpression Predicts Poor Prognosis in Intrahepatic Cholangiocarcinoma. Gastroenterology Research and Practice،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1159700
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ning, Shanglei…[et al.]. SHMT2 Overexpression Predicts Poor Prognosis in Intrahepatic Cholangiocarcinoma. Gastroenterology Research and Practice No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1159700
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ning, Shanglei& Ma, Siquan& Saleh, Abdul Qahar& Guo, Lingyu& Zhao, Zixiao& Chen, Yuxin. SHMT2 Overexpression Predicts Poor Prognosis in Intrahepatic Cholangiocarcinoma. Gastroenterology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1159700
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1159700
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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