IRF7 Gene Variations Confer Susceptibility to Autoimmune Thyroid Diseases and Graves’ Ophthalmopathy
المؤلفون المشاركون
An, Xiaofei
Yao, Qiu-ming
Li, Ling
Song, Rong-hua
Zhang, Jin-an
Mu, Kaida
Zhang, Jing
Sun, Peilong
المصدر
International Journal of Endocrinology
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-01-15
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
The objective of this study was to investigate whether IRF7 polymorphisms are associated with autoimmune thyroid diseases (AITDs).
We selected three single nucleotide polymorphisms (SNPs) of IRF7, namely, rs1061501, rs1131665, and rs1061502 for genotyping using PCR-based ligase detection reaction (LDR) method in a total of 1659 participants (592 with Graves’ disease, 297 with Hashimoto’s thyroiditis, and 770 healthy controls).
Gene-disease and genotype-clinical phenotype associations were evaluated for the three SNPs.
Our results showed that the AG genotype and the minor allele G frequency of rs1131665 and rs1061502 in AITD patients were both higher than those of the controls (rs1131665: AG genotype: P=0.017, OR=1.968; allele G: P=0.018, OR=1.946; rs1061502: AG genotype: P=0.029, OR=1.866; allele G: P=0.031, OR=1.847).
Subgroup analysis also showed that the AG genotype and the minor allele G frequency of rs1131665 and rs1061502 in Graves’ disease patients were both higher than those of the controls (rs1131665: AG genotype: P=0.015, OR=2.074; allele G: P=0.016, OR=2.048; rs1061502: AG genotype: P=0.034, OR=1.919; allele G: P=0.035, OR=1.898).
Furthermore, the allele G frequency of rs1061501 was associated with Graves’ ophthalmopathy (P=0.035, OR=1.396).
No significant difference in IRF7 polymorphisms was found between Hashimoto’s thyroiditis patients and controls.
Our study has revealed for the first time that IRF7 is a susceptibility gene for AITD, especially for Graves’ disease and Graves’ ophthalmopathy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yao, Qiu-ming& An, Xiaofei& Zhang, Jing& Mu, Kaida& Li, Ling& Song, Rong-hua…[et al.]. 2019. IRF7 Gene Variations Confer Susceptibility to Autoimmune Thyroid Diseases and Graves’ Ophthalmopathy. International Journal of Endocrinology،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1159711
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yao, Qiu-ming…[et al.]. IRF7 Gene Variations Confer Susceptibility to Autoimmune Thyroid Diseases and Graves’ Ophthalmopathy. International Journal of Endocrinology No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1159711
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yao, Qiu-ming& An, Xiaofei& Zhang, Jing& Mu, Kaida& Li, Ling& Song, Rong-hua…[et al.]. IRF7 Gene Variations Confer Susceptibility to Autoimmune Thyroid Diseases and Graves’ Ophthalmopathy. International Journal of Endocrinology. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1159711
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1159711
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر