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Expression of PAPP-A2 and IGF Pathway-Related Proteins in the Hip Joint of Normal Rat and Those with Developmental Dysplasia of the Hip
المؤلفون المشاركون
Chen, Yufan
Lv, Haixiang
Li, Lianyong
Wang, Enbo
Zhang, Lijun
Zhao, Qun
المصدر
International Journal of Endocrinology
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-02-20
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Developmental dysplasia of the hip (DDH) is one of the major causes of child disability and early osteoarthritis.
Genetic factors play an important role, but which still remain unclear.
Pregnancy-associated plasma protein-A2 (PAPP-A2), a special hydrolase of insulin-like growth factor binding protein-5 (IGFBP-5), has been confirmed to be associated with DDH by previous studies.
The aim of this study was firstly, to investigate the expression of PAPP-A2 and insulin-like growth factor (IGF) pathway-related proteins in normal rat’s hip joints; secondly, to compare the variations of those proteins between DDH model rats and normal ones.
The DDH model was established by swaddling the rat’s hind legs in hip adduction and extension position.
The hip joints were collected for expression study of fetal rats, normal newborn rats, and DDH model rats.
Positive expression of PAPP-A2 and IGF pathway-related proteins was observed in all the hip joints of growing-stage rats.
Ultimately, IGF1 was downregulated; insulin-like growth factor 1 receptor (IGF1R) showed an opposite trend in DDH rats when compared with normal group.
The PAPP-A2 and IGF pathway-associated proteins may also be involved in the development of the rat’s hip joint, which bring the foundation for further revealing the pathogenic mechanism of DDH.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Yufan& Lv, Haixiang& Li, Lianyong& Wang, Enbo& Zhang, Lijun& Zhao, Qun. 2019. Expression of PAPP-A2 and IGF Pathway-Related Proteins in the Hip Joint of Normal Rat and Those with Developmental Dysplasia of the Hip. International Journal of Endocrinology،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1159742
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Yufan…[et al.]. Expression of PAPP-A2 and IGF Pathway-Related Proteins in the Hip Joint of Normal Rat and Those with Developmental Dysplasia of the Hip. International Journal of Endocrinology No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1159742
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Yufan& Lv, Haixiang& Li, Lianyong& Wang, Enbo& Zhang, Lijun& Zhao, Qun. Expression of PAPP-A2 and IGF Pathway-Related Proteins in the Hip Joint of Normal Rat and Those with Developmental Dysplasia of the Hip. International Journal of Endocrinology. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1159742
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1159742
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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