![](/images/graphics-bg.png)
Comparison of Concomitant Mesalamine and Immunomodulator Therapy and Immunomodulator Monotherapy for Crohn’s Disease
المؤلفون المشاركون
Byeon, Jung Sik
Yang, Dong-Hoon
Kwak, Min Seob
Kim, Kyung-Jo
Cheon, Jae Hee
Kim, Wan Soo
Lee, Jeong-Mi
Hwang, Sung Wook
Park, Sang Hyoung
Ye, Byong Duk
Myung, Seung-Jae
Yang, Suk-Kyun
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-01-18
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
Although immunomodulators are increasingly used in Crohn’s disease (CD), a significant number of gastroenterologists still use 5-aminosalicylate (5-ASA) in combination with azathioprine (AZA) or 6-mercaptopurine (6-MP); there is limited evidence regarding the benefit of concomitant 5-ASA with AZA/6-MP compared with AZA/6-MP monotherapy for the treatment of CD.
Study Design.
A total of 106 patients who received AZA/6-MP for more than 3 months between January 1991 and May 2014 were identified retrospectively.
Each patient was matched with 3 randomly selected controls who were treated with concomitant therapy during the same period.
Results.
The cumulative probabilities of steroid use at 5 and 10 years were 24.9% and 75.8% in the 5-ASA + AZA/6-MP group and 31.2% and 87.8% in the AZA/6-MP group, respectively (P=0.187).
The cumulative probabilities of anti-TNF use, resectional surgery, and disease-related hospitalization were comparable between the groups.
The younger age and the use of lower doses of immunomodulators were associated with higher requirement of rescue therapy.
Conclusions.
This study did not demonstrate that the concomitant use of 5-ASA with AZA/6-MP showed the proof or effect in terms of steroid requirements, anti-TNF use, resectional surgery, or disease-related hospitalization compared with that of AZA/6-MP alone.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kwak, Min Seob& Kim, Kyung-Jo& Cheon, Jae Hee& Kim, Wan Soo& Lee, Jeong-Mi& Hwang, Sung Wook…[et al.]. 2018. Comparison of Concomitant Mesalamine and Immunomodulator Therapy and Immunomodulator Monotherapy for Crohn’s Disease. Gastroenterology Research and Practice،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1159745
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kwak, Min Seob…[et al.]. Comparison of Concomitant Mesalamine and Immunomodulator Therapy and Immunomodulator Monotherapy for Crohn’s Disease. Gastroenterology Research and Practice No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1159745
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kwak, Min Seob& Kim, Kyung-Jo& Cheon, Jae Hee& Kim, Wan Soo& Lee, Jeong-Mi& Hwang, Sung Wook…[et al.]. Comparison of Concomitant Mesalamine and Immunomodulator Therapy and Immunomodulator Monotherapy for Crohn’s Disease. Gastroenterology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1159745
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1159745
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)