Wingless-Type MMTV Integration Site Family Member 5a Is a Key Secreted Islet Stellate Cell-Derived Product that Regulates Islet Function
المؤلفون المشاركون
Lu, Jun
Xu, Wei
Sun, Zilin
Liang, Jun
Geng, H. F.
Li, Rui
Wang, X. L.
Lv, Qian
Liu, Ying
Wang, Jie
Liu, X. K.
Jones, Peter M.
المصدر
International Journal of Endocrinology
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-04-11
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
Emerging evidence suggests that T2DM is attributable to the dysfunction of β-cells and the activation of islet stellate cells (ISCs).
The wingless-type MMTV integration site family member 5a (Wnt5a)/frizzled 5 (Fzd5) signalling pathway might take part in this process.
Our study is aimed at defining the status of ISCs during β-cell insulin secretion homeostasis by determining the role of the Wnt5a protein in the regulation of insulin production.
We examined the effects of the status of ISCs on β-cell insulin secretion in normoglycemic db/m and hyperglycaemic db/db mice.
Methods.
iTRAQ protein screening and RNA interference were used to determine novel ISC-derived secretory products that may use other mechanisms to influence the function of islets.
Results.
We showed a significant reduction in insulin secretion by β-cells in vitro when they were cocultured with db/db ISCs compared to when they were cocultured with ISCs isolated from normoglycemic db/m mice; in addition, both Wnt5a and its receptor Fzd5 were more highly expressed by quiescent ISCs than by activated db/db ISCs.
Treatment with exogenous Wnt5a increased the secretion of insulin in association with the deactivation of ISCs.
Conclusion.
Our observations revealed that the Wnt5a protein is a key effector of ISC-mediated improvement in islet function.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xu, Wei& Liang, Jun& Geng, H. F.& Lu, Jun& Li, Rui& Wang, X. L.…[et al.]. 2019. Wingless-Type MMTV Integration Site Family Member 5a Is a Key Secreted Islet Stellate Cell-Derived Product that Regulates Islet Function. International Journal of Endocrinology،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1160054
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xu, Wei…[et al.]. Wingless-Type MMTV Integration Site Family Member 5a Is a Key Secreted Islet Stellate Cell-Derived Product that Regulates Islet Function. International Journal of Endocrinology No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1160054
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xu, Wei& Liang, Jun& Geng, H. F.& Lu, Jun& Li, Rui& Wang, X. L.…[et al.]. Wingless-Type MMTV Integration Site Family Member 5a Is a Key Secreted Islet Stellate Cell-Derived Product that Regulates Islet Function. International Journal of Endocrinology. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1160054
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1160054
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر