Effect of acute and chronic lead nitrate exposure on some physiological parameters in experimental mice

الملخص EN

The research include the study of the effect of lead in the form of lead nitrate on some hematological parameters ( Hb concentration, total WBC count, differential WBC count) and liver enzymes, glutamate-pyruvate transaminase (GPT) or (ALT) and glutamate-oxaloacetate transaminase (GOT) or (AST) levels during the acute and chronic exposure in experimental mice, the research performed by feeding the mice to two different concentration of lead nitrate 50 ppm / kg and 100 ppm / kg for two exposure periods the acute (10 days) and chronic (20 days).

The results showed that the lead in 50 ppm / kg con.

in chronic period showed much less decrease in hemoglobin concentration, neutrophils percentage ( 6.9 g /100ml, 12.25% respectively) than in the acute period (9 g / 100 ml, 18.5% respectively) and an increase in total WBCs count, basophils, eosinophils and lymphocytes percentage (5.01 ×103,2.25% , 4% and 65.25% respectively) much than in the acute period( 3.11×103, 0.75%, 0.75%, 63.25% respectively) , AST level increase significantly in the acute period of 100 ppm / kg exposure whereas ALT level increase significantly in the acute period of 50 ppm / kg exposure, we also found that females were more hematologic ally affected with lead compared with males while the AST and ALT levels were high in males than females for both periods.