TG : HDL-C Ratio Is a Good Marker to Identify Children Affected by Obesity with Increased Cardiometabolic Risk and Insulin Resistance
المؤلفون المشاركون
Wan Mohamud, Wan Nazaimoon
Nur Zati Iwani, Ahmad Kamil
Wan Mohd Zin, Ruziana Mona
Fuziah, Md Zain
Hong, Janet Yeow Hua
Abqariyah, Yahya
Mokhtar, Abdul Halim
Jalaludin, Muhammad Yazid
المصدر
International Journal of Endocrinology
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-12-01
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Metabolic syndrome (MetS) is an important predictor of cardiovascular diseases in adulthood.
This study aims to examine the clinical utility of triglyceride to high-density lipoprotein ratio (TG : HDL-C) in identifying cardiometabolic risk and insulin resistance (IR) among children with obesity, in comparison with MetS as defined by the International Diabetes Federation (IDF).
Data of 232 children with obesity aged 10–16 years were obtained from our study, MyBFF@school study, conducted between January and December 2014.
Children were divided into tertiles of TG : HDL-C ratio.
The minimum value of the highest tertile was 1.11.
Thus, elevated TG : HDL-C ratio was defined as TG : HDL-C ≥1.11.
Children with MetS were categorized based on the definition established by the IDF.
Out of 232 children, 23 (9.9%) had MetS, out of which 5.6% were boys.
Almost twofold of boys and girls had elevated TG : HDL-C ratio compared to MetS: 13.8% vs.
5.6% and 13.8% vs.
4.3%, respectively.
Children with elevated TG : HDL-C ratio had lower fasting glucose compared to children with MetS (boys = 5.15 ± 0.4 vs.
6.34 ± 2.85 mmol/l, p=0.02; girls = 5.17 ± 0.28 vs.
6.8 ± 4.3 mmol/l, p=0.03).
Additionally, boys with elevated TG : HDL-C ratio had a higher HDL-C level compared to those with MetS (1.08 ± 0.18 vs.
0.96 ± 0.1 mmol/l, p=0.03).
There was no significant difference across other MetS-associated risk factors.
Overall, TG : HDL-C ratio demonstrated higher sensitivity (42.7% vs.
12.9%) but lower specificity (74.8% vs.
93.2%) than MetS in identifying IR, either in HOMA-IR ≥2.6 for prepubertal children or HOMA-IR ≥4 for pubertal children.
TG : HDL-C ratio in children with obesity is thus as useful as the diagnosis of MetS.
It should be considered an additional component to MetS, especially as a surrogate marker for IR.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nur Zati Iwani, Ahmad Kamil& Jalaludin, Muhammad Yazid& Wan Mohd Zin, Ruziana Mona& Fuziah, Md Zain& Hong, Janet Yeow Hua& Abqariyah, Yahya…[et al.]. 2019. TG : HDL-C Ratio Is a Good Marker to Identify Children Affected by Obesity with Increased Cardiometabolic Risk and Insulin Resistance. International Journal of Endocrinology،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1165052
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nur Zati Iwani, Ahmad Kamil…[et al.]. TG : HDL-C Ratio Is a Good Marker to Identify Children Affected by Obesity with Increased Cardiometabolic Risk and Insulin Resistance. International Journal of Endocrinology No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1165052
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nur Zati Iwani, Ahmad Kamil& Jalaludin, Muhammad Yazid& Wan Mohd Zin, Ruziana Mona& Fuziah, Md Zain& Hong, Janet Yeow Hua& Abqariyah, Yahya…[et al.]. TG : HDL-C Ratio Is a Good Marker to Identify Children Affected by Obesity with Increased Cardiometabolic Risk and Insulin Resistance. International Journal of Endocrinology. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1165052
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1165052
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر