Analysis of Prognostic Factors for Resected Synchronous and Metachronous Liver Metastases from Colorectal Cancer
المؤلفون المشاركون
Taddei, A.
Boni, L.
Bechi, P.
Bartolini, Ilenia
Ringressi, Maria Novella
Melli, Filippo
Risaliti, Matteo
Brugia, Marco
Mini, Enrico
Batignani, Giacomo
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-07-11
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Background.
Surgical treatment is the cornerstone in the management of colorectal cancer (CRC) liver metastases.
The aim of this study is to identify clinicopathological factors affecting disease-free (DFS) and overall survival (OS) in patients undergoing potentially curative liver resection for CRC metastasis.
Methods.
All consecutive patients undergoing liver resection for first recurrence of CRC from February 2006 to February 2018 were included.
Prognostic impact of factors related to the patient, primary and metastatic tumors, was retrospectively tested through univariate and multivariate analyses.
Results.
Seventy patients were included in the study.
Median postoperative follow-up was 37 months (range 1–119).
Median DFS and OS were 15.2 and 62.7 months, and 5-year DFS and OS rates were 16% and 53%.
In univariate analysis, timing of metastasis presentation/treatment (combined colorectal and liver resection, “bowel first” approach or metachronous presentation) (p<0.0001), ASA score (p=0.003), chemotherapy after liver surgery (p=0.028), T stage (p=0.021), number of resected liver lesions (p<0.0001), and liver margin status (p=0.032) was significantly associated with DFS while peritoneal resection at colorectal surgery (p=0.026), ASA score (p=0.036), extension of liver resection (p=0.024), chemotherapy after liver surgery (p=0.047), and positive nodes (p=0.018) with OS.
In multivariate analysis, timing of metastasis presentation/treatment, ASA score, and chemotherapy (before and after liver surgery) resulted significantly associated with DFS and timing of metastasis presentation/treatment, positive nodes, peritoneal resection at colorectal surgery, and surgical approach (open or minimally invasive) of colorectal resection with OS.
Conclusions.
Surgery may provide good DFS and OS rates for CRC liver metastasis.
Patient selection for surgery and correct timing of intervention within a multidisciplinary approach may be improved by taking into account negative prognostic factors which stress the importance of systemic therapy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bartolini, Ilenia& Ringressi, Maria Novella& Melli, Filippo& Risaliti, Matteo& Brugia, Marco& Mini, Enrico…[et al.]. 2018. Analysis of Prognostic Factors for Resected Synchronous and Metachronous Liver Metastases from Colorectal Cancer. Gastroenterology Research and Practice،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1165075
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bartolini, Ilenia…[et al.]. Analysis of Prognostic Factors for Resected Synchronous and Metachronous Liver Metastases from Colorectal Cancer. Gastroenterology Research and Practice No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1165075
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bartolini, Ilenia& Ringressi, Maria Novella& Melli, Filippo& Risaliti, Matteo& Brugia, Marco& Mini, Enrico…[et al.]. Analysis of Prognostic Factors for Resected Synchronous and Metachronous Liver Metastases from Colorectal Cancer. Gastroenterology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1165075
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1165075
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر