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The Value of Fecal Microbiota Transplantation in the Treatment of Ulcerative Colitis Patients: A Systematic Review and Meta-Analysis
المؤلفون المشاركون
Cao, Yantian
Zhang, Bangjie
Wu, Yuanyuan
Wang, Qingzhi
Wang, Jie
Shen, Fangfang
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-04-03
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Background and Aims.
Fecal microbiota transplantation (FMT) has challenged the traditional management of ulcerative colitis (UC) in recent years, while it remained controversial.
We aimed to provide a systematic protocol of FMT treatment on UC.
Methods.
Studies reporting on FMT treatment in UC patients were performed.
A fixed-effect model was used to assess the efficacy of FMT.
Results.
Eighteen studies were enrolled (n=446).
A pooled proportion of patients who received FMT had a significant efficacy compared to the placebo group (odds ratio (OR): 2.73, P=0.002) with a low risk of heterogeneity (P=0.59, I2=0%).
The Mayo score decreased to 5 points in a state of mild–moderate activity after FMT treatment, and the optimal range of the Mayo score baseline was 6–9 for FMT administration.
Then, the baseline of the Shannon diversity index (SDI) had a negative correlation with the clinical response rate (R=−0.992, P=0.08) or remission rate (R=−0.998, P=0.036), and the optimal diversity of bacteria was at 7 days to one month.
Moreover, the colonoscopy delivery and unrelated fecal donor had slight superiorities of FMT treatment.
Conclusion.
FMT treatment had a higher efficacy and shorter time-point of early assessment of effectiveness on UC patients compared to traditional therapies.
And the optimal FMT delivery and donor were colonoscopy delivery and unrelated donor in clinical practice.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cao, Yantian& Zhang, Bangjie& Wu, Yuanyuan& Wang, Qingzhi& Wang, Jie& Shen, Fangfang. 2018. The Value of Fecal Microbiota Transplantation in the Treatment of Ulcerative Colitis Patients: A Systematic Review and Meta-Analysis. Gastroenterology Research and Practice،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1165091
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cao, Yantian…[et al.]. The Value of Fecal Microbiota Transplantation in the Treatment of Ulcerative Colitis Patients: A Systematic Review and Meta-Analysis. Gastroenterology Research and Practice No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1165091
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cao, Yantian& Zhang, Bangjie& Wu, Yuanyuan& Wang, Qingzhi& Wang, Jie& Shen, Fangfang. The Value of Fecal Microbiota Transplantation in the Treatment of Ulcerative Colitis Patients: A Systematic Review and Meta-Analysis. Gastroenterology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1165091
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1165091
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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