![](/images/graphics-bg.png)
Selective Electrochemical Determination of Etoposide Using a Molecularly Imprinted Overoxidized Polypyrrole Coated Glassy Carbon Electrode
المؤلفون المشاركون
Hrichi, Hajer
Monser, Lotfi
Adhoum, Nafaâ
المصدر
International Journal of Electrochemistry
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-01-02
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
A simple and efficient new electrochemical sensor based on molecularly imprinted polymer has been developed for selective detection of an anticancer agent Etoposide (ETP).
The sensor was prepared by electropolymerization via cyclic voltammetry (CV) of pyrrole onto a glassy carbon electrode (GCE) in the presence of ETP molecules.
The extraction of ETP molecules embedded in the polymeric matrix was carried out by overoxidation in sodium hydroxide medium using CV.
Various important parameters affecting the performance of the imprinted film (MIP) coated sensor were studied and optimized using differential pulse voltammetry (DPV).
Under optimal conditions, the sensor response exhibited a linear dependence on ETP concentration (R2 = 0.999) over the range 5.0×10−7 M – 1.0×10−5 M with a LOD (3σ/m) of 2.8×10−9 M.
The precision (% RSD, n=6) of the proposed sensor for intra- and interdays was found to be 0.84 and 2.46%, respectively.
The selectivity of MIP/GCE sensor toward ETP was investigated in the presence of different interfering molecules including excipients and ETP metabolites.
The developed sensor showed great recognition ability toward ETP and was successfully applied for its determination in injectable dosage forms and biological human fluids.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hrichi, Hajer& Monser, Lotfi& Adhoum, Nafaâ. 2019. Selective Electrochemical Determination of Etoposide Using a Molecularly Imprinted Overoxidized Polypyrrole Coated Glassy Carbon Electrode. International Journal of Electrochemistry،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1165197
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hrichi, Hajer…[et al.]. Selective Electrochemical Determination of Etoposide Using a Molecularly Imprinted Overoxidized Polypyrrole Coated Glassy Carbon Electrode. International Journal of Electrochemistry No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1165197
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hrichi, Hajer& Monser, Lotfi& Adhoum, Nafaâ. Selective Electrochemical Determination of Etoposide Using a Molecularly Imprinted Overoxidized Polypyrrole Coated Glassy Carbon Electrode. International Journal of Electrochemistry. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1165197
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1165197
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)