Helicobacter pylori Eradication in Idiopathic Thrombocytopenic Purpura: A Meta-Analysis of Randomized Trials
المؤلفون المشاركون
Kim, Bum Jun
Jang, Hyun Joo
Kim, Jung Han
Kim, Hyeong Su
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-10-09
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Objective.
Several recent reviews of published studies have shown that the eradication of H.
pylori infection in patients with ITP improved thrombocytopenia in about half of the cases.
However, most included studies were observational case series.
We performed the first meta-analysis of randomized trials to gain a better insight into the effect of H.
pylori eradication in ITP patients.
Methods.
A systematic computerized search of the electronic databases including PubMed, EMBASE, Google Scholar, and Cochrane Library (up to December 2017) was conducted.
Results.
From six studies, a total of 241 patients (125 in eradication group and 116 in control group) were included in the meta-analysis.
Patients in the eradication group showed significantly higher overall platelet response rate than those in the control group (odds ratio = 1.93, 95% confidence interval: 1.01–3.71, P=0.05).
In the subgroup analysis, however, children in the eradication group failed to show statistically better response rate than those in the noneradication group (odds ratio = 1.80, 95% confidence interval: 0.88–3.65, P=0.11).
Conclusions.
This meta-analysis indicates that H.
pylori eradication has a significant therapeutic effect in patients with ITP.
Considering the intrinsic limits in the design and sample size of the included studies, however, large randomized controlled trials are warranted to validate the therapeutic impact of H.
pylori eradication in adults as well as children with ITP.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kim, Bum Jun& Kim, Hyeong Su& Jang, Hyun Joo& Kim, Jung Han. 2018. Helicobacter pylori Eradication in Idiopathic Thrombocytopenic Purpura: A Meta-Analysis of Randomized Trials. Gastroenterology Research and Practice،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1165228
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kim, Bum Jun…[et al.]. Helicobacter pylori Eradication in Idiopathic Thrombocytopenic Purpura: A Meta-Analysis of Randomized Trials. Gastroenterology Research and Practice No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1165228
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kim, Bum Jun& Kim, Hyeong Su& Jang, Hyun Joo& Kim, Jung Han. Helicobacter pylori Eradication in Idiopathic Thrombocytopenic Purpura: A Meta-Analysis of Randomized Trials. Gastroenterology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1165228
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1165228
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر