Effect of Endotoxemia in Suckling Rats on Pancreatic Integrity and Exocrine Function in Adults: A Review Report
المؤلفون المشاركون
Pierzchalski, Piotr
Jaworek, Andrzej K.
Bonior, Joanna
Kot, Michalina
Ceranowicz, Piotr
Warzecha, Zygmunt
Dembiński, Artur
Gil, Krzysztof
Tudek, Barbara
Kowalczyk, Paweł
Leja-Szpak, Anna
Nawrot-Porąbka, Katarzyna
Szklarczyk, Joanna
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-01-14
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Background.
Endotoxin (LPS), the component of Gram-negative bacteria, is responsible for sepsis and neonatal mortality, but low concentrations of LPS produced tissue protection in experimental studies.
The effects of LPS applied to the suckling rats on the pancreas of adult animals have not been previously explored.
We present the impact of neonatal endotoxemia on the pancreatic exocrine function and on the acute pancreatitis which has been investigated in the adult animals.
Endotoxemia was induced in suckling rats by intraperitoneal application of LPS from Escherichia coli or Salmonella typhi.
In the adult rats, pretreated in the early period of life with LPS, histological manifestations of acute pancreatitis have been reduced.
Pancreatic weight and plasma lipase activity were decreased, and SOD concentration was reversed and accompanied by a significant reduction of lipid peroxidation products (MDA + 4 HNE) in the pancreatic tissue.
In the pancreatic acini, the significant increases in protein signals for toll-like receptor 4 and for heat shock protein 60 were found.
Signal for the CCK1 receptor was reduced and pancreatic secretory responses to caerulein were diminished, whereas basal enzyme secretion was unaffected.
These pioneer studies have shown that exposition of suckling rats to endotoxin has an impact on the pancreas in the adult organism.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jaworek, Andrzej K.& Tudek, Barbara& Kowalczyk, Paweł& Kot, Michalina& Szklarczyk, Joanna& Leja-Szpak, Anna…[et al.]. 2018. Effect of Endotoxemia in Suckling Rats on Pancreatic Integrity and Exocrine Function in Adults: A Review Report. Gastroenterology Research and Practice،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1165408
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jaworek, Andrzej K.…[et al.]. Effect of Endotoxemia in Suckling Rats on Pancreatic Integrity and Exocrine Function in Adults: A Review Report. Gastroenterology Research and Practice No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1165408
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jaworek, Andrzej K.& Tudek, Barbara& Kowalczyk, Paweł& Kot, Michalina& Szklarczyk, Joanna& Leja-Szpak, Anna…[et al.]. Effect of Endotoxemia in Suckling Rats on Pancreatic Integrity and Exocrine Function in Adults: A Review Report. Gastroenterology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1165408
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1165408
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر