Mean Corpuscular Volume as a Predictive Factor of Response to Preoperative Chemoradiotherapy in Locally Advanced Rectal Cancer
المؤلفون المشاركون
Chen, Xingxing
Zhang, Wenyi
Zou, Changlin
Chen, Wen-Hao
Zhang, Hui
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-03-18
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
The aim of this study was to identify if blood routine parameters and serum tumor marker are potential predictive factors for tumor response to preoperative chemoradiotherapy (CRT) in locally advanced rectal cancer.
Materials and Methods.
55 locally advanced rectal cancer patients were treated with preoperative CRT in this study.
The total dose of preoperative radiotherapy was 45 Gy in 25 fractions of 1.8 in 5 weeks.
All patients concurrently received 825 mg/m2 capecitabine orally twice daily on days 1 to 14 and 22 to 35.
Total mesorectal excision (TME) was performed 6 weeks after the end of preoperative CRT.
Blood routine examination and serum tumor marker were checked before preoperative CRT.
Tumor response to preoperative CRT was evaluated with the semiquantitative tumor regression grading (TRG) system proposed by Dworak criteria according to histopathological examination of the surgical specimens.
Univariable and multivariable logistic regression analyses were used to test the association between blood routine parameters and serum tumor marker and tumor response to preoperative CRT.
Results.
Univariate logistic regression analysis revealed that differentiation, lymphocyte, LMR, MCV, PLR, and CEA have been significantly associated with tumor response to preoperative CRT.
Multivariate logistic regression analysis revealed that differentiation, MCV, and CEA were the predictors of tumor response to preoperative CRT.
According to the ROC analysis, the AUC of differentiation, MCV, and CEA was 0.794, 0.802, and 0.723, respectively.
Optimal cutoff points for MCV and CEA were 87.65 fl and 4.05 ng/ml, respectively.
Conclusion.
MCV is a potential predictive factor for tumor response to preoperative chemoradiation in locally advanced rectal cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Wenyi& Chen, Xingxing& Chen, Wen-Hao& Zhang, Hui& Zou, Changlin. 2018. Mean Corpuscular Volume as a Predictive Factor of Response to Preoperative Chemoradiotherapy in Locally Advanced Rectal Cancer. Gastroenterology Research and Practice،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1165430
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Wenyi…[et al.]. Mean Corpuscular Volume as a Predictive Factor of Response to Preoperative Chemoradiotherapy in Locally Advanced Rectal Cancer. Gastroenterology Research and Practice No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1165430
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Wenyi& Chen, Xingxing& Chen, Wen-Hao& Zhang, Hui& Zou, Changlin. Mean Corpuscular Volume as a Predictive Factor of Response to Preoperative Chemoradiotherapy in Locally Advanced Rectal Cancer. Gastroenterology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1165430
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1165430
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر