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Prognostic Value of MUC2 Expression in Colorectal Cancer: A Systematic Review and Meta-Analysis
المؤلفون المشاركون
Li, Chao
Zuo, Didi
Liu, Tao
Yin, Libin
Wang, Lei
Lin, Yuyang
Li, Chenguang
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-06-05
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Background.
The reliability of MUC2 as a prognostic marker in colorectal cancer (CRC) is controversial.
This study evaluated the association between MUC2 expression levels in CRC tissues and prognosis.
Methods.
The PubMed, Web of Science, Embase, Cochrane Library, China Biology Medicine disc (CBMdisc), Wanfang Database, and China National Knowledge Infrastructure (CNKI) databases were searched to identify studies exploring the relationship between MUC2 expression in CRC tissues and overall survival (OS).
Pooled hazard ratios (HRs) and risk ratios (RRs) with 95% confidence intervals (CIs) were used to evaluate the associations between MUC2 expression levels and prognosis and MUC2 expression levels and CRC clinicopathological characteristics, respectively.
Results.
The meta-analysis included 11 studies (2619 patients).
Low MUC2 expression level was significantly associated with poor OS (HR, 1.67; 95% CI, 1.43–1.94; P<0.00001) and disease-free survival (DFS)/recurrence-free survival (RFS) (HR, 1.60; 95% CI, 1.21–2.12; P=0.001) in patients with CRC.
Low MUC2 expression level was associated with advanced TNM stage (RR, 1.42; 95% CI, 1.26–1.60; P<0.00001), lymph node metastasis (RR, 1.41; 95% CI, 1.25–1.60; P<0.00001), lymphatic invasion (RR,1.64; 95% CI, 1.26–2.12; P=0.0002), rectal tumor site (RR, 1.26; 95% CI, 1.09–1.46; P=0.001), and large tumor size (RR,1.32; 95% CI, 1.02–1.70; P=0.03).
There were no associations between low MUC2 expression level and gender, histological grade, depth of invasion, and distant metastasis.
Conclusion.
The low levels of MUC2 in CRC tissues are poor prognostic factor independent of stage or other well-recognized markers of later-stage disease.
Large well-designed cohort studies are required to validate MUC2 as a biomarker for poor prognosis in CRC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Chao& Zuo, Didi& Yin, Libin& Lin, Yuyang& Li, Chenguang& Liu, Tao…[et al.]. 2018. Prognostic Value of MUC2 Expression in Colorectal Cancer: A Systematic Review and Meta-Analysis. Gastroenterology Research and Practice،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1165432
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Chao…[et al.]. Prognostic Value of MUC2 Expression in Colorectal Cancer: A Systematic Review and Meta-Analysis. Gastroenterology Research and Practice No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1165432
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Chao& Zuo, Didi& Yin, Libin& Lin, Yuyang& Li, Chenguang& Liu, Tao…[et al.]. Prognostic Value of MUC2 Expression in Colorectal Cancer: A Systematic Review and Meta-Analysis. Gastroenterology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1165432
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1165432
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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