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Different Anatomical Subsites of Colon Cancer and Mortality: A Population-Based Study
المؤلفون المشاركون
Sun, Leimin
Si, Jianmin
He, Xing-kang
Wu, Wenrui
Ding, Yu-e
Li, Yue
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-08-30
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
In terms of incidence and pathogenesis, right-sided colon cancer (RCC) and left-sided colon cancer (LCC) exhibit several differences.
However, whether existing differences could reflect the different survival outcomes remains unclear.
Therefore, we aimed to ascertain the role of location in the prognosis.
Methods.
We identified colon cancer cases from the Surveillance, Epidemiology, and End Results database between 1973 and 2012.
Differences among subsites of colon cancer regarding clinical features and metastatic patterns were compared.
The Kaplan-Meier curves were conducted to compare overall and disease-specific survival in relation to cancer location.
The effect of tumour location on overall and cancer-specific survival was analysed by Cox proportional hazards model.
Results.
A total of 377,849 patients from SEER database were included in the current study, with 180,889 (47.9%) RCC and 196,960 (52.1%) LCC.
LCC was more likely to metastasize to the liver and lung.
Kaplan-Meier curves demonstrated that LCC patients had better overall and cancer-specific survival outcomes.
Among Cox multivariate analyses, LCC was associated with a slightly reduced risk of overall survival (HR, 0.92; 95% CI, 0.92-0.93) and cancer-specific survival (HR, 0.92; 95% CI, 0.91-0.93), even after adjusted for other variables.
However, the relationship between location and prognosis was varied by subgroups defined by age, year at diagnosis, stage, and therapies.
Conclusions.
We demonstrated that LCC was associated with better prognosis, especially for patients with distant metastasis.
Future trails should seek to identify the underlying mechanism.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
He, Xing-kang& Wu, Wenrui& Ding, Yu-e& Li, Yue& Sun, Leimin& Si, Jianmin. 2018. Different Anatomical Subsites of Colon Cancer and Mortality: A Population-Based Study. Gastroenterology Research and Practice،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1165460
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
He, Xing-kang…[et al.]. Different Anatomical Subsites of Colon Cancer and Mortality: A Population-Based Study. Gastroenterology Research and Practice No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1165460
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
He, Xing-kang& Wu, Wenrui& Ding, Yu-e& Li, Yue& Sun, Leimin& Si, Jianmin. Different Anatomical Subsites of Colon Cancer and Mortality: A Population-Based Study. Gastroenterology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1165460
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1165460
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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