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A Retrospective Study Analyzing the Appropriateness of Initial Treatment of Clostridium difficile in Patients with Active Malignancy
المؤلفون المشاركون
Orosey, Molly
Hader, Ismail
Halalau, Alexandra
Fisher, Aaron
Yadav, Siddhartha
Khanal, Pradeep
Gniado, Ewa
Khaddour, Leila
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-05-27
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
Clostridium difficile infection (CDI) is the leading cause of hospital-associated gastrointestinal illness.
Previous studies reported that patients with active malignancy are at high risk for CDIs, and yet they are still classified as nonsevere CDI and initially treated with metronidazole.
Our aim is to investigate the need for the escalation of antibiotic therapy in patients with CDI and active cancer treated with oral metronidazole versus oral vancomycin.
Methods.
This is a retrospective study of adult patients admitted with CDI and any underlying active malignancy at Beaumont Hospital, Royal Oak, Michigan, from January 2008 to December 2014.
Inclusion criteria included age > 18 years old, polymerase chain reaction- (PCR-) proven CDI, and active malignancy.
Results.
197 patients were included in the final analysis.
44.8% of the metronidazole group required escalation of therapy compared to 15.2% in the vancomycin group (p value = 0.001).
29.8% of the combination group (metronidazole and vancomycin) underwent deescalation of antibiotics, which was significantly higher compared to 2.2% of patients in the vancomycin group (p value < 0.001).
Discussion.
Our results support the initial use of vancomycin or a combination (metronidazole and vancomycin) versus metronidazole in patients with CDI and active malignancy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fisher, Aaron& Khanal, Pradeep& Gniado, Ewa& Khaddour, Leila& Orosey, Molly& Hader, Ismail…[et al.]. 2018. A Retrospective Study Analyzing the Appropriateness of Initial Treatment of Clostridium difficile in Patients with Active Malignancy. Gastroenterology Research and Practice،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1165470
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fisher, Aaron…[et al.]. A Retrospective Study Analyzing the Appropriateness of Initial Treatment of Clostridium difficile in Patients with Active Malignancy. Gastroenterology Research and Practice No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1165470
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fisher, Aaron& Khanal, Pradeep& Gniado, Ewa& Khaddour, Leila& Orosey, Molly& Hader, Ismail…[et al.]. A Retrospective Study Analyzing the Appropriateness of Initial Treatment of Clostridium difficile in Patients with Active Malignancy. Gastroenterology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1165470
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1165470
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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