Cyclooxygenase-2 Expression Is a Predictive Marker for Late Recurrence in Colorectal Cancer
المؤلفون المشاركون
Lee, Kang Hong
Paik, Seung Sam
Kim, Sung Hoo
Ahn, Byung Kyu
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-06-24
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Introduction.
Cyclooxygenase-2 (COX-2) expression is elevated in colorectal cancer (CRC).
However, data about the relation between COX-2 expression and the impact on the biologic behavior of recurrent disease are inconclusive as yet.
The aim of this study is to investigate the relationship between the status of COX-2 expression in the primary CRC and the characteristics of recurrence after curative resection of stage I to III CRC.
Materials and Methods.
Ninety-eight patients with recurrence in 376 CRC patients, who underwent curative surgery between January 1991 and August 2001, were retrospectively assessed.
Immunohistochemical staining, performed for the presence of COX-2 on tissue microarrays, was analyzed.
Results.
Forty-six patients showed elevated COX-2 expression, and 52 patients did not.
The mean time to recurrence was significantly longer in the positive group than in the negative group (34.1 months ± 30.0 versus 21.9 months ± 17.4; P=0.019).
Positive COX-2 expression was correlated with late recurrence (>3 years after surgery) [43.5% versus 13.5%; P=0.001].
In multivariate analysis, COX-2 expression was an independent factor associated with late recurrence (OR 4.656; 95% CI, 1.696 to 12.779; P=0.003).
Recurrence pattern and postrecurrence survival were not different between the two groups.
Conclusions.
Elevated COX-2 expression in itself is not a prognostic factor, but COX-2 expression in tumor tissue may be an independent predictive marker of late recurrence for patients with stage I to III CRC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kim, Sung Hoo& Ahn, Byung Kyu& Paik, Seung Sam& Lee, Kang Hong. 2018. Cyclooxygenase-2 Expression Is a Predictive Marker for Late Recurrence in Colorectal Cancer. Gastroenterology Research and Practice،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1165610
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kim, Sung Hoo…[et al.]. Cyclooxygenase-2 Expression Is a Predictive Marker for Late Recurrence in Colorectal Cancer. Gastroenterology Research and Practice No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1165610
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kim, Sung Hoo& Ahn, Byung Kyu& Paik, Seung Sam& Lee, Kang Hong. Cyclooxygenase-2 Expression Is a Predictive Marker for Late Recurrence in Colorectal Cancer. Gastroenterology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1165610
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1165610
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر