Genus-Wide Comparative Genomics Analysis of Neisseria to Identify New Genes Associated with Pathogenicity and Niche Adaptation of Neisseria Pathogens
المؤلفون المشاركون
Cao, De-Min
Lu, Qun-Feng
Li, Song-Bo
Wang, Ju-Ping
Su, Li-Li
Ye, Guang-Bin
Zhu, Xiao-Ying
المصدر
International Journal of Genomics
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-19، 19ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-01-15
دولة النشر
مصر
عدد الصفحات
19
التخصصات الرئيسية
الملخص EN
N.
gonorrhoeae and N.
meningitidis, the only two human pathogens of Neisseria, are closely related species.
But the niches they survived in and their pathogenic characteristics are distinctly different.
However, the genetic basis of these differences has not yet been fully elucidated.
In this study, comparative genomics analysis was performed based on 15 N.
gonorrhoeae, 75 N.
meningitidis, and 7 nonpathogenic Neisseria genomes.
Core-pangenome analysis found 1111 conserved gene families among them, and each of these species groups had opening pangenome.
We found that 452, 78, and 319 gene families were unique in N.
gonorrhoeae, N.
meningitidis, and both of them, respectively.
Those unique gene families were regarded as candidates that related to their pathogenicity and niche adaptation.
The relationships among them have been partly verified by functional annotation analysis.
But at least one-third genes for each gene set have not found the certain functional information.
Simple sequence repeat (SSR), the basis of gene phase variation, was found abundant in the membrane or related genes of each unique gene set, which may facilitate their adaptation to variable host environments.
Protein-protein interaction (PPI) analysis found at least five distinct PPI clusters in N.
gonorrhoeae and four in N.
meningitides, and 167 and 52 proteins with unknown function were contained within them, respectively.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lu, Qun-Feng& Cao, De-Min& Su, Li-Li& Li, Song-Bo& Ye, Guang-Bin& Zhu, Xiao-Ying…[et al.]. 2019. Genus-Wide Comparative Genomics Analysis of Neisseria to Identify New Genes Associated with Pathogenicity and Niche Adaptation of Neisseria Pathogens. International Journal of Genomics،Vol. 2019, no. 2019, pp.1-19.
https://search.emarefa.net/detail/BIM-1165670
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lu, Qun-Feng…[et al.]. Genus-Wide Comparative Genomics Analysis of Neisseria to Identify New Genes Associated with Pathogenicity and Niche Adaptation of Neisseria Pathogens. International Journal of Genomics No. 2019 (2019), pp.1-19.
https://search.emarefa.net/detail/BIM-1165670
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lu, Qun-Feng& Cao, De-Min& Su, Li-Li& Li, Song-Bo& Ye, Guang-Bin& Zhu, Xiao-Ying…[et al.]. Genus-Wide Comparative Genomics Analysis of Neisseria to Identify New Genes Associated with Pathogenicity and Niche Adaptation of Neisseria Pathogens. International Journal of Genomics. 2019. Vol. 2019, no. 2019, pp.1-19.
https://search.emarefa.net/detail/BIM-1165670
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1165670
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر