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In Vitro Susceptibility and Florfenicol Resistance in Citrobacter Isolates and Whole-Genome Analysis of Multidrug-Resistant Citrobacter freundii
المؤلفون المشاركون
Bao, Qiyu
Lu, Junwan
Qian, Changrui
Chen, Qianqian
Shen, Kai
Li, Kewei
Zhou, Wangxiao
Zhu, Xinyi
Zhou, Danying
Lu, Wei
Sun, Zhewei
Liu, Hongmao
Xu, Teng
المصدر
International Journal of Genomics
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-11-19
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
The genus Citrobacter is an opportunistic pathogen causing infections in animals, and the published data for its resistance to florfenicol are scarce.
In this study, we investigated the antimicrobial susceptibility and molecular characteristics of florfenicol resistance genes among Citrobacter isolates from animal and relevant environmental samples and conducted a comparative analysis of a multidrug-resistant Citrobacter freundii strain isolated from a rabbit.
Among 20 Citrobacter strains isolated from animal samples, resistance was most commonly observed to ampicillin (100%), tetracycline (75%), streptomycin (65%), florfenicol (60%), chloramphenicol (60%), and aztreonam (50%), while all the strains found in environmental samples were resistant to few antibiotics.
The florfenicol resistance gene floR was detected in 12 isolates (48%, 12/25) from animal samples, and all of the floR-positive isolates were resistant to florfenicol with minimum inhibitory concentration (MIC) values ≥256 μg/mL.
Sequencing and comparative analysis of the plasmids from a multidrug-resistant C.
freundii isolate named R47 showed that the floR-containing region in the plasmid pR47-54 was a truncated transposon-like structure and could be found on both plasmids and chromosomes of bacteria of either animal or human origin.
Furthermore, a range of antimicrobial and metal resistance genes associated with mobile genetic elements could be identified in pR47-54 and the other plasmid pR47-309 of C.
freundii R47.
These results provide in-depth views into the phenotypic and molecular characteristics of Citrobacter isolates recovered from animal and relevant environmental samples, as well as highlight the role horizontal gene transfer plays in the dissemination of plasmid-encoded resistance genes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhou, Wangxiao& Chen, Qianqian& Qian, Changrui& Shen, Kai& Zhu, Xinyi& Zhou, Danying…[et al.]. 2019. In Vitro Susceptibility and Florfenicol Resistance in Citrobacter Isolates and Whole-Genome Analysis of Multidrug-Resistant Citrobacter freundii. International Journal of Genomics،Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1165710
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhou, Wangxiao…[et al.]. In Vitro Susceptibility and Florfenicol Resistance in Citrobacter Isolates and Whole-Genome Analysis of Multidrug-Resistant Citrobacter freundii. International Journal of Genomics No. 2019 (2019), pp.1-15.
https://search.emarefa.net/detail/BIM-1165710
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhou, Wangxiao& Chen, Qianqian& Qian, Changrui& Shen, Kai& Zhu, Xinyi& Zhou, Danying…[et al.]. In Vitro Susceptibility and Florfenicol Resistance in Citrobacter Isolates and Whole-Genome Analysis of Multidrug-Resistant Citrobacter freundii. International Journal of Genomics. 2019. Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1165710
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1165710
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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