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Cell-Free DNA Plasma Levels Differ in Age-Specific Pattern in Healthy Rats and Castrates with Testosterone-Induced Benign Prostatic Hyperplasia
المؤلفون المشاركون
Bespalov, Vladimir
Vasilyeva, I. N.
Von, J. D.
Semenov, A. L.
Tochilnikov, G. V.
Romanov, V. A.
Alvovsky, I. K.
Baranenko, D. A.
المصدر
International Journal of Genomics
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-06-02
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
The purpose of this work was to study changes in the level of cell-free DNA (cfDNA) in the blood of young and old rats in the normal state and with induced benign prostatic hyperplasia (BPH).
Male Wistar rats were divided into 4 groups—young (3 months), old (20 months), intact, or with testosterone-induced BPH.
Groups with BPH were subjected to surgical castration and administration of testosterone esters at a dose of 25 mg/kg for a total of 7 injections for 20 days.
In intact animals, the level of cfDNA in old rats (2.00±0.14 ng/μl) was significantly higher than that in the young (1.02±0.30 ng/μl).
The body and the prostate weights of old rats were 1.6 and 1.4 times larger than those of the young, without an increase in the prostate index (PI).
The testosterone level in the blood of young rats was 1.6 times higher than that of old (6.20±0.93 nmol/l vs.
3.77±0.55 nmol/l; NS).
In animals with BPH, the level of cfDNA in old rats (3.14±0.76 ng/μl) was significantly higher than that in young rats (0.80±0.14 ng/μl).
The body and the prostate weights in old rats were 1.8 and 2.3 times larger, than those in young rats, with an increase in the PI.
The level of testosterone in the blood of young (15.76±0.51 nmol/l) and old (16.99±1.1 nmol/l) rats was not significantly different.
Morphological signs of BPH were observed in the prostate of both young and old rats.
During the induction of BPH in the experiment, according to the level of cfDNA, cell death processes have not changed significantly in young rats but significantly increased in old rats.
A similar trend was observed in the group of intact animals.
The obtained data indicate that apoptosis processes are enhanced during the development of BPH despite the growth of tissues in the prostate itself.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Vasilyeva, I. N.& Bespalov, Vladimir& Von, J. D.& Semenov, A. L.& Tochilnikov, G. V.& Romanov, V. A.…[et al.]. 2019. Cell-Free DNA Plasma Levels Differ in Age-Specific Pattern in Healthy Rats and Castrates with Testosterone-Induced Benign Prostatic Hyperplasia. International Journal of Genomics،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1165759
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Vasilyeva, I. N.…[et al.]. Cell-Free DNA Plasma Levels Differ in Age-Specific Pattern in Healthy Rats and Castrates with Testosterone-Induced Benign Prostatic Hyperplasia. International Journal of Genomics No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1165759
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Vasilyeva, I. N.& Bespalov, Vladimir& Von, J. D.& Semenov, A. L.& Tochilnikov, G. V.& Romanov, V. A.…[et al.]. Cell-Free DNA Plasma Levels Differ in Age-Specific Pattern in Healthy Rats and Castrates with Testosterone-Induced Benign Prostatic Hyperplasia. International Journal of Genomics. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1165759
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1165759
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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