Association of FMO3 Variants with Blood Pressure in the Atherosclerosis Risk in Communities Study
المؤلفون المشاركون
Bryant, Tyler S.
Duggal, Priya
Yu, Bing
Morrison, Alanna C.
Shafi, Tariq
Ehret, Georg
Franceschini, Nora
Coresh, Josef
Tin, Adrienne
Boerwinkle, Eric
المصدر
International Journal of Hypertension
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-02-18
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Flavin containing monooxygenase 3 [FMO3] encodes dimethylaniline monooxygenase [N-oxide-forming] 3, which breaks down nitrogen-containing compounds, and has been implicated in blood pressure regulation.
Studies have reported conflicting results of the association of a common nonsynonymous variant, E158K (rs2266782), with hypertension.
We examined the associations of E158K, along with rare and low frequency exonic variants (minor allele frequency [MAF]<5%) in FMO3 with hypertension, systolic blood pressure (SBP), and diastolic blood pressure (DBP).
We included 7,350 European Americans and 2,814 African Americans in the Atherosclerosis Risk in Communities (ARIC) study with exome sequencing of FMO3.
The association of FMO3 variants with SBP and DBP was tested using single variant and gene-based tests followed by the replication or interrogation of significant variants in ancestry-specific cohorts based on Bonferroni corrected thresholds.
E158K had significant association with higher SBP in African Americans in ARIC (p=0.03), and two low frequency variants had significant association with higher SBP in African Americans (rs200985584, MAF 0.1%, p=0.0003) and European Americans (rs75904274, MAF 1.7%, p=0.006).
These associations were not significant with additional samples: E158K in a meta-analysis of SBP of African ancestry (N=30,841, p=0.43) that included ARIC participants and the two low frequency variants in an independent ancestry-specific exome sequencing study of blood pressure (rs200985584, p=0.94; rs75904274, p=0.81).
Our study does not support the association of E158K and low frequency variants in FMO3 with blood pressure and demonstrates the importance of replication in genetic studies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bryant, Tyler S.& Duggal, Priya& Yu, Bing& Morrison, Alanna C.& Shafi, Tariq& Ehret, Georg…[et al.]. 2019. Association of FMO3 Variants with Blood Pressure in the Atherosclerosis Risk in Communities Study. International Journal of Hypertension،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1165972
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bryant, Tyler S.…[et al.]. Association of FMO3 Variants with Blood Pressure in the Atherosclerosis Risk in Communities Study. International Journal of Hypertension No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1165972
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bryant, Tyler S.& Duggal, Priya& Yu, Bing& Morrison, Alanna C.& Shafi, Tariq& Ehret, Georg…[et al.]. Association of FMO3 Variants with Blood Pressure in the Atherosclerosis Risk in Communities Study. International Journal of Hypertension. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1165972
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1165972
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر