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Impact of Serum Uric Acid Levels on Outcomes following Renal Artery Revascularization in Patients with Renovascular Disease
المؤلفون المشاركون
Misra, Sanjay
Chen, Xiao-jun
Eirin, Alfonso
Kane, Garvan C.
Textor, Stephen C.
Lerman, Amir
Lerman, Lilach O.
المصدر
International Journal of Hypertension
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-01-30
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
Percutaneous transluminal renal angioplasty (PTRA) improves blood pressure (BP) and renal function only in selected patients with atherosclerotic renovascular disease (ARVD).
Hyperuricemia is associated with elevated risk for hypertension and chronic renal disease, but its role in renovascular hypertension is unclear.
We hypothesized that hyperuricemia negatively impacts renal and BP outcomes among patients with ARVD undergoing PTRA.
Methods.
This retrospective, observational cohort study included 94 patients with ARVD and preserved systolic cardiac function, who underwent PTRA at Mayo Clinic, Rochester, Minnesota.
Renal, BP, and mortality outcomes were compared among patients according to their serum uric acid (SUA) levels.
Multivariate analysis was used to determine significant predictors of renal, BP, and mortality outcomes after PTRA.
Results.
Compared to patients with normal basal SUA levels (≤5.7 mg/dl), patients with very high SUA (≥8.7 mg/dl) had lower baseline estimated glomerular filtration rate (eGFR), more extensive use of antihypertensive and diuretic drugs, increased baseline systolic blood pressure (SBP), and elevated left ventricular mass index.
After PTRA, multiple logistic regression analysis showed that, compared to normal SUA, very high SUA was associated with decreased odds ratio (OR) of change in eGFR (adjusted OR=0.90; 95% confidence interval [CI], 0.86-0.95), but not of change in SBP.
In multivariate linear analysis SUA independently predicted delta urine protein/creatinine ratio (β: 26.0; 95% confidence interval, 13.9 to 38.1).
Conclusion.
Severe hyperuricemia in patients with AVRD may have a negative impact on outcomes of renal revascularization.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Xiao-jun& Eirin, Alfonso& Kane, Garvan C.& Misra, Sanjay& Textor, Stephen C.& Lerman, Amir…[et al.]. 2019. Impact of Serum Uric Acid Levels on Outcomes following Renal Artery Revascularization in Patients with Renovascular Disease. International Journal of Hypertension،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1166002
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Xiao-jun…[et al.]. Impact of Serum Uric Acid Levels on Outcomes following Renal Artery Revascularization in Patients with Renovascular Disease. International Journal of Hypertension No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1166002
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Xiao-jun& Eirin, Alfonso& Kane, Garvan C.& Misra, Sanjay& Textor, Stephen C.& Lerman, Amir…[et al.]. Impact of Serum Uric Acid Levels on Outcomes following Renal Artery Revascularization in Patients with Renovascular Disease. International Journal of Hypertension. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1166002
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1166002
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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