Melatonin as an Anti-Inflammatory Agent Modulating Inflammasome Activation
المؤلفون المشاركون
Rodella, Luigi Fabrizio
Rezzani, Rita
Bonomini, Francesca
Franceschetti, Lorenzo
Favero, Gaia
المصدر
International Journal of Endocrinology
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-10-01
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Inflammation may be defined as the innate response to harmful stimuli such as pathogens, injury, and metabolic stress; its ultimate function is to restore the physiological homeostatic state.
The exact aetiology leading to the development of inflammation is not known, but a combination of genetic, epigenetic, and environmental factors seems to play an important role in the pathogenesis of many inflammation-related clinical conditions.
Recent studies suggest that the pathogenesis of different inflammatory diseases also involves the inflammasomes, intracellular multiprotein complexes that mediate activation of inflammatory caspases thereby inducing the secretion of proinflammatory cytokines.
Melatonin, an endogenous indoleamine, is considered an important multitasking molecule with fundamental clinical applications.
It is involved in mood modulation, sexual behavior, vasomotor control, and immunomodulation and influences energy metabolism; moreover, it acts as an oncostatic and antiaging molecule.
Melatonin is an important antioxidant and also a widespread anti-inflammatory molecule, modulating both pro- and anti-inflammatory cytokines in different pathophysiological conditions.
This review, first, gives an overview concerning the growing importance of melatonin in the inflammatory-mediated pathological conditions and, then, focuses on its roles and its protective effects against the activation of the inflammasomes and, in particular, of the NLRP3 inflammasome.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Favero, Gaia& Franceschetti, Lorenzo& Bonomini, Francesca& Rodella, Luigi Fabrizio& Rezzani, Rita. 2017. Melatonin as an Anti-Inflammatory Agent Modulating Inflammasome Activation. International Journal of Endocrinology،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1166011
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Favero, Gaia…[et al.]. Melatonin as an Anti-Inflammatory Agent Modulating Inflammasome Activation. International Journal of Endocrinology No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1166011
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Favero, Gaia& Franceschetti, Lorenzo& Bonomini, Francesca& Rodella, Luigi Fabrizio& Rezzani, Rita. Melatonin as an Anti-Inflammatory Agent Modulating Inflammasome Activation. International Journal of Endocrinology. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1166011
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1166011
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر