Contribution of Four Polymorphisms in Renin-Angiotensin-Aldosterone-Related Genes to Hypertension in a Thai Population
المؤلفون المشاركون
Thongmung, Nisakron
Sritara, Piyamitr
Kitiyakara, Chagriya
Charoen, Pimphen
Eu-ahsunthornwattana, Jakris
Jose, Pedro A.
Vathesatogkit, Prin
المصدر
International Journal of Hypertension
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-08-14
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Introduction.
The roles of genes in the renin-angiotensin-aldosterone system (RAAS) in hypertension, including angiotensin-converting enzyme (ACE), angiotensinogen (AGT), angiotensin II receptor type 1 (AGTR1), and aldosterone synthase (CYP11B2), have been widely studied across different ethnicities, but there has been no such investigation in Thai population.
Materials and Methods.
Using 4,150 Thais recorded in the Electricity Generating Authority of Thailand (EGAT) study, we examined the association of rs1799752, rs699, rs5186, and rs1799998 located in or near ACE, AGT, AGTR1, and CYP11B2 genes in hypertension.
We investigated their roles in hypertension using multivariate logistic regression and further examined their roles in blood pressure (BP) using quantile regression.
Sex, age, and BMI were adjusted as potential confounders.
Results.
We did not observe associations between hypertension and rs1799752 (P=0.422), rs699 (P=0.36), rs5186 (P=0.49), and rs1799998 (P=0.71).
No evidence of association between these SNPs and BP was found across an entire distribution.
A nonlinear relationship between age and BP was observed.
Conclusion.
In Thai population, our study showed no evidence of association between RAAS-related genes and hypertension.
While our study is the first and largest study to investigate the role of RAAS-related genes in hypertension in Thai population, restricted statistical power due to limited sample size is a limitation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Charoen, Pimphen& Eu-ahsunthornwattana, Jakris& Thongmung, Nisakron& Jose, Pedro A.& Sritara, Piyamitr& Vathesatogkit, Prin…[et al.]. 2019. Contribution of Four Polymorphisms in Renin-Angiotensin-Aldosterone-Related Genes to Hypertension in a Thai Population. International Journal of Hypertension،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1166013
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Charoen, Pimphen…[et al.]. Contribution of Four Polymorphisms in Renin-Angiotensin-Aldosterone-Related Genes to Hypertension in a Thai Population. International Journal of Hypertension No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1166013
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Charoen, Pimphen& Eu-ahsunthornwattana, Jakris& Thongmung, Nisakron& Jose, Pedro A.& Sritara, Piyamitr& Vathesatogkit, Prin…[et al.]. Contribution of Four Polymorphisms in Renin-Angiotensin-Aldosterone-Related Genes to Hypertension in a Thai Population. International Journal of Hypertension. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1166013
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1166013
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر