Serum Concentrations of Betatrophin and Its Association with Indirect Indices of Insulin Resistance and Beta Cell Function in Women with Polycystic Ovary Syndrome
المؤلفون المشاركون
Hryniewicka, Justyna
Wolczynski, Slawomir
Adamska, Agnieszka
Łebkowska, Agnieszka
Jacewicz, Małgorzata
Krentowska, Anna
Kowalska, Irina
Górska, Maria
المصدر
International Journal of Endocrinology
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-06-18
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Introduction.
Data underline the role of betatrophin in glucose homeostasis.
Polycystic ovary syndrome (PCOS) is characterized by insulin resistance (IR).
The aim of our study was to investigate the relationship of serum betatrophin concentrations with indirect indices of IR and insulin secretion in women with PCOS, compared to the control group.
Methods.
The study group comprised 43 women with PCOS and 16 controls.
IR was assessed by HOMA-IR and Matsuda index.
Insulin secretion was evaluated with HOMA-B.
An oral glucose tolerance test (OGTT) with estimation of serum betatrophin concentrations was performed.
Results.
Glucose load resulted in an increase in serum betatrophin concentrations in the control group (p=0.02).
Serum betatrophin concentrations at 120 min of OGTT were lower in women with PCOS than in the control group (p=0.02).
We observed positive correlations between baseline serum betatrophin concentrations and HOMA-IR (r=0.39, p=0.008), negative correlations with Matsuda index (r=−0.31, p=0.004), and a positive relationship with HOMA-B (r=0.38, p=0.01) in women with PCOS.
Multiple regression analysis revealed that HOMA-B (β=0.47, p=0.001) was an independent factor connected to serum betatrophin levels in PCOS.
Conclusions.
Serum concentrations of betatrophin are connected with insulin resistance and beta cell function and did not change after glucose load in women with PCOS.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Adamska, Agnieszka& Łebkowska, Agnieszka& Jacewicz, Małgorzata& Krentowska, Anna& Hryniewicka, Justyna& Wolczynski, Slawomir…[et al.]. 2017. Serum Concentrations of Betatrophin and Its Association with Indirect Indices of Insulin Resistance and Beta Cell Function in Women with Polycystic Ovary Syndrome. International Journal of Endocrinology،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1166047
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Adamska, Agnieszka…[et al.]. Serum Concentrations of Betatrophin and Its Association with Indirect Indices of Insulin Resistance and Beta Cell Function in Women with Polycystic Ovary Syndrome. International Journal of Endocrinology No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1166047
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Adamska, Agnieszka& Łebkowska, Agnieszka& Jacewicz, Małgorzata& Krentowska, Anna& Hryniewicka, Justyna& Wolczynski, Slawomir…[et al.]. Serum Concentrations of Betatrophin and Its Association with Indirect Indices of Insulin Resistance and Beta Cell Function in Women with Polycystic Ovary Syndrome. International Journal of Endocrinology. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1166047
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1166047
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر