Vaccine Development against the Renin-Angiotensin System for the Treatment of Hypertension
المؤلفون المشاركون
Azegami, Tatsuhiko
Itoh, Hiroshi
المصدر
International Journal of Hypertension
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-08-14
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Hypertension is a global public health issue and the most important preventable cause of cardiovascular diseases.
Despite the clinical availability of many antihypertensive drugs, many hypertensive patients have poor medication adherence and blood pressure control due, at least partially, to the asymptomatic and chronic characteristics of hypertension.
Immunotherapeutic approaches have the potential to improve medication adherence in hypertension because they induce prolonged therapeutic effects and need a low frequency of administration.
The first attempts to reduce blood pressure by using vaccines targeting the renin-angiotensin system were made more than half a century ago; however, at the time, a poor understanding of immunology and the mechanisms of hypertension and a lack of optimal vaccine technologies such as suitable antigen design, proper adjuvants, and effective antigen delivery systems meant that attempts to develop antihypertensive vaccines failed.
Recent advances in immunology and vaccinology have provided potential therapeutic immunologic approaches to treat not only infectious diseases but also cancers and other noncommunicable diseases.
One important biotechnology that has had a major impact on modern vaccinology is virus-like particle technology, which can efficiently deliver vaccine antigens without the need for artificial adjuvants.
A human clinical trial that indicated the effectiveness and safety of a virus-like particle-based antiangiotensin II vaccine marked a turning point in the field of therapeutic antihypertensive vaccines.
Here, we review the history of the development of immunotherapies for the treatment of hypertension and discuss the current perspectives in the field.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Azegami, Tatsuhiko& Itoh, Hiroshi. 2019. Vaccine Development against the Renin-Angiotensin System for the Treatment of Hypertension. International Journal of Hypertension،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1166084
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Azegami, Tatsuhiko& Itoh, Hiroshi. Vaccine Development against the Renin-Angiotensin System for the Treatment of Hypertension. International Journal of Hypertension No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1166084
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Azegami, Tatsuhiko& Itoh, Hiroshi. Vaccine Development against the Renin-Angiotensin System for the Treatment of Hypertension. International Journal of Hypertension. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1166084
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1166084
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر