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Rapid Action of Aldosterone on Protein Levels of Sodium-Hydrogen Exchangers and Protein Kinase C Beta Isoforms in Rat Kidney
المؤلفون المشاركون
Eiam-Ong, Somchai
Eiam-Ong, Somchit
Manotham, Krissanapong
Chaipipat, Mookda
المصدر
International Journal of Endocrinology
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-10-22
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Previous in vitro studies demonstrated that aldosterone rapidly activates sodium-hydrogen exchangers 1 and 3 (NHE 1 and 3).
In vitro investigations revealed that protein kinase C (PKC) regulates NHE properties.
We previously demonstrated that aldosterone rapidly enhances PKCα protein abundance in the rat kidney.
There are no reports of renal PKCβ (I and II) protein levels related to the regulation by aldosterone.
There are also no in vivo data regarding the rapid effects of aldosterone on renal protein levels of NHE (1 and 3) and PKCβ (I and II), simultaneously.
In the current study, rats received normal saline solution or aldosterone (150 μg/kg BW, i.p.).
After 30 minutes, abundance and immunoreactivity of these proteins were determined by Western blot analysis and immunohistochemistry, respectively.
Aldosterone increased NHE1 and NHE3 protein abundance to 152% and 134%, respectively (P<0.05).
PKCβI protein level was enhanced by 30%, whereas PKCβII declined slightly.
Aldosterone increased NHE protein expression mostly in the medulla.
PKCβI immunostaining intensity was increased in the glomeruli, renal vasculature, and thin limb of the loop of Henle, while PKCβII was reduced.
This is the first in vivo study to simultaneously demonstrate that aldosterone rapidly elevates PKCβI and NHE (1 and 3) protein abundance in the rat kidney.
Aldosterone-induced NHE (1 and 3) protein levels may be related to PKCβI activation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Eiam-Ong, Somchit& Chaipipat, Mookda& Manotham, Krissanapong& Eiam-Ong, Somchai. 2017. Rapid Action of Aldosterone on Protein Levels of Sodium-Hydrogen Exchangers and Protein Kinase C Beta Isoforms in Rat Kidney. International Journal of Endocrinology،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1166096
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Eiam-Ong, Somchit…[et al.]. Rapid Action of Aldosterone on Protein Levels of Sodium-Hydrogen Exchangers and Protein Kinase C Beta Isoforms in Rat Kidney. International Journal of Endocrinology No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1166096
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Eiam-Ong, Somchit& Chaipipat, Mookda& Manotham, Krissanapong& Eiam-Ong, Somchai. Rapid Action of Aldosterone on Protein Levels of Sodium-Hydrogen Exchangers and Protein Kinase C Beta Isoforms in Rat Kidney. International Journal of Endocrinology. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1166096
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1166096
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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