Effect of Low-Level Laser Therapy (LLLT)‎ in Pulmonary Inflammation in Asthma Induced by House Dust Mite (HDM)‎: Dosimetry Study

المؤلفون المشاركون

Lino-dos-Santos-Franco, Adriana
Vieira, Rodolfo P.
Rigonato-Oliveira, Nicole Cristine
Brito, Auriléia Aparecida de
Vitoretti, Luana Beatriz
de Cunha Moraes, Gabriel
Gonçalves, Tawany
Herculano, Karine Zanella
Alves, Cintia Estefano
Aimbire, Flávio
Ligeiro de Oliveira, Ana Paula

المصدر

International Journal of Inflammation

العدد

المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-12، 12ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2019-03-21

دولة النشر

مصر

عدد الصفحات

12

التخصصات الرئيسية

الأمراض
الطب البشري

الملخص EN

Asthma is characterized by chronic inflammation in the airways.

Several models have been proposed for the discovery of new therapies.

Low-Level Laser Therapy (LLLT) is relatively new and effective, very low cost, with no side effects.

However, there is still no consensus on the optimal dose to be used.

In this sense, the objective of the present study was to evaluate the best dose in an experimental model of asthma induced by House Dust Mite (HDM).

Balb/c mice received administration of 100 ug/animal HDM and LLLT applications (diode laser: 660 nm, 100 mW and four different energies 1J, 3J, 5J, and 7.5J) for 16 days.

After 24 hours, we studied inflammatory, functional, and structural parameters.

The results showed that LBI was able to modulate the pulmonary inflammation observed by reducing the number of cells in Bronchoalveolar Lavage Fluid (BALF) as well as reducing the percentage of neutrophils, eosinophils and T lymphocytes.

On the other hand, LLLT increased the level of IL-10 and reduced levels of IL-4, IL-5 and IL-13 in BALF.

LLLT was able to reduce the production of mucus, peribronchial eosinophils, collagen deposition, bronchoconstriction index, and bronchial and muscular thickening in the airways.

We concluded that the use of LLLT in the treatment of chronic inflammation of the airways attenuated the inflammatory process and functional and structural parameters.

We emphasize, in general, that the 1J and 3J laser presented better results.

Thus, photobiomodulation may be considered a promising tool for the treatment of chronic pulmonary allergic inflammation observed in asthma.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Rigonato-Oliveira, Nicole Cristine& Brito, Auriléia Aparecida de& Vitoretti, Luana Beatriz& de Cunha Moraes, Gabriel& Gonçalves, Tawany& Herculano, Karine Zanella…[et al.]. 2019. Effect of Low-Level Laser Therapy (LLLT) in Pulmonary Inflammation in Asthma Induced by House Dust Mite (HDM): Dosimetry Study. International Journal of Inflammation،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1166111

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Rigonato-Oliveira, Nicole Cristine…[et al.]. Effect of Low-Level Laser Therapy (LLLT) in Pulmonary Inflammation in Asthma Induced by House Dust Mite (HDM): Dosimetry Study. International Journal of Inflammation No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1166111

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Rigonato-Oliveira, Nicole Cristine& Brito, Auriléia Aparecida de& Vitoretti, Luana Beatriz& de Cunha Moraes, Gabriel& Gonçalves, Tawany& Herculano, Karine Zanella…[et al.]. Effect of Low-Level Laser Therapy (LLLT) in Pulmonary Inflammation in Asthma Induced by House Dust Mite (HDM): Dosimetry Study. International Journal of Inflammation. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1166111

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1166111