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Antibiotic Use and Resistance Pattern in Ethiopia: Systematic Review and Meta-Analysis
المؤلف
المصدر
International Journal of Microbiology
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-08-01
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
In the last decades, medicines have had an unprecedented positive effect on health, leading to reduced mortality and disease burden and consequently to an improved quality of life.
The rapid and ongoing spread of antimicrobial-resistant organisms threatens our ability to successfully treat a growing number of infectious diseases.
In the absence of the development of new generations of antibiotic drugs, appropriate use of existing antibiotics is needed to ensure the long-term availability of effective treatment for bacterial infections.
Irrational use of antibiotics is an ongoing global public health problem that deserves more attention.
This review is conducted to evaluate the prevalence of inappropriate antibiotic utilization and resistance to antibiotics in Ethiopia.
Methods.
Electronic search in PubMed/MEDLINE and Google was used to find published literature with reference lists of relevant articles searched manually.
Titles and abstracts were initially screened for eligibility.
The full texts of articles judged to be eligible were reviewed if they meet the inclusion criteria.
Data were extracted on important variables like the sample size, region of the study, the inappropriate antibiotic use, bacterial detection rate, multidrug resistance pattern, and more other variables.
Microsoft Excel was used for data extraction.
Quantitative analysis was performed using STATA version 11.
Results.
The electronic searches identified 193 articles of which 33 were found eligible.
The random-effects model was used to provide point estimates (with 95% confidence interval (CI)) of bacterial detection rate, inappropriate antibiotic use, and multidrug resistance rate to account for heterogeneity.
The pooled bacteria detection rate was 29.1 with 95% CI (16.6–41.7).
The pooled prevalence of multidrug resistant strains identified was 59.7% (95% CI: 43.5–75.9).
The pooled estimate of inappropriate antibiotic use was 49.2% (95% CI: 32.2–66.2).
The pooled proportion of self-antibiotic prescription was 43.3% (95% CI: 15.7–70.9).
Other reasons for inappropriate antibiotic use included a wrong indication, wrong duration, improper route of administration, use of leftover antibiotics from a family member, and immature discontinuation of antibiotics.
Conclusion and Recommendations.
Inappropriate antibiotic use is a huge problem in Ethiopia, and many bacteria were resistant to commonly used antibiotics and similarly, multidrug-resistant bacterial strains are numerous.
Appropriate antibiotic use should be ensured by prohibiting over-the-counter sale of antibiotics and strengthening antimicrobial stewardship.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Muhie, Oumer Abdu. 2019. Antibiotic Use and Resistance Pattern in Ethiopia: Systematic Review and Meta-Analysis. International Journal of Microbiology،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1166186
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Muhie, Oumer Abdu. Antibiotic Use and Resistance Pattern in Ethiopia: Systematic Review and Meta-Analysis. International Journal of Microbiology No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1166186
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Muhie, Oumer Abdu. Antibiotic Use and Resistance Pattern in Ethiopia: Systematic Review and Meta-Analysis. International Journal of Microbiology. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1166186
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1166186
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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