Central Precocious Puberty and Response to GnRHa Therapy in Children with Cerebral Palsy and Moderate to Severe Motor Impairment: Data from a Longitudinal, Case-Control, Multicentre, Italian Study
المؤلفون المشاركون
Bruzzi, Patrizia
De Luca, Filippo
Verrotti, Alberto
Messina, Maria Francesca
Bartoli, Alessandra
Lucaccioni, Laura
Madeo, Simona Filomena
Iughetti, Lorenzo
Predieri, Barbara
المصدر
International Journal of Endocrinology
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-07-16
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
Children affected by neurodevelopmental disability could experience early pubertal changes at least 20 times more than the general population.
Limited data about central precocious puberty (CPP) among children affected by cerebral palsy (CP) are available.
Methods.
This is a longitudinal, observational, retrospective, case-control study involving 22 children affected by CPP and CP (group A), 22 paired with CP but without CPP (group B), and 22 children with CPP without CP.
Auxological, biochemical, and instrumental data were collected at diagnosis of CPP and at 2 follow-up visits.
Results.
No differences were detected between groups A (at baseline) and B.
At diagnosis of CPP, height SDS adjusted for target height (H-TH SDS) was significantly reduced in A than in C (−0.63 ± 1.94 versus 1.56 ± 1.38), while basal LH and oestradiol levels were significantly elevated in A than in C.
During follow-up, despite an effective treatment, growth impairment deteriorated in A than in C (Δ H-SDS from diagnosis of CPP to last follow-up: −0.49 ± 0.91 versus 0.21 ± 0.33, p=0.023).
Conclusions.
Diagnosis of CPP could be partially mislead in CP due to growth failure that got worse during follow-up despite therapy.
CPP in CP seems to progress rapidly along time supporting the hypothesis of a more intense activation of hypothalamic-pituitary-gonadal-axis in these patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bruzzi, Patrizia& Messina, Maria Francesca& Bartoli, Alessandra& Predieri, Barbara& Lucaccioni, Laura& Madeo, Simona Filomena…[et al.]. 2017. Central Precocious Puberty and Response to GnRHa Therapy in Children with Cerebral Palsy and Moderate to Severe Motor Impairment: Data from a Longitudinal, Case-Control, Multicentre, Italian Study. International Journal of Endocrinology،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1166347
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bruzzi, Patrizia…[et al.]. Central Precocious Puberty and Response to GnRHa Therapy in Children with Cerebral Palsy and Moderate to Severe Motor Impairment: Data from a Longitudinal, Case-Control, Multicentre, Italian Study. International Journal of Endocrinology No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1166347
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bruzzi, Patrizia& Messina, Maria Francesca& Bartoli, Alessandra& Predieri, Barbara& Lucaccioni, Laura& Madeo, Simona Filomena…[et al.]. Central Precocious Puberty and Response to GnRHa Therapy in Children with Cerebral Palsy and Moderate to Severe Motor Impairment: Data from a Longitudinal, Case-Control, Multicentre, Italian Study. International Journal of Endocrinology. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1166347
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1166347
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر