Crosstalk between Aryl Hydrocarbon Receptor and Glucocorticoid Receptor in Human Retinal Pigment Epithelial Cells
المؤلفون المشاركون
Jin, Hong Lan
Choi, Yujin
Jeong, Kwang Won
المصدر
International Journal of Endocrinology
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-03-22
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The aryl hydrocarbon receptor (AHR) is known to mediate the cellular reaction involved in processing environmental contaminants and, ultimately, preventing accumulation of unfavorable extra lipids and proteins.
Glucocorticoid receptor (GR) mediates the expression of genes associated with anti-inflammatory properties.
Because AHR and GR are closely related in lipid metabolic dysregulation and inflammation, we speculate that AHR and GR may play a crucial role in AMD pathogenesis and focus on their crosstalk in human retinal pigment epithelial cells (ARPE-19).
However, how AHR and GR regulate each other’s signaling pathways is still poorly understood.
In this research, we demonstrate that GR attenuates AHR-mediated gene expression by inhibition of nuclear translocation of AHR mediated by TCDD.
Chromatin immunoprecipitation analysis demonstrated that GR repress AHR recruitment and chromatin accessibility response to TCDD + Dex treatment leading to repression of AHR target genes.
In contrast, AHR facilitates GR-mediated expression in ARPE-19.
AHR increases GR recruitment on GRE of GR target genes.
Coimmunoprecipitation assay revealed that AHR is associated with GR in ARPE-19 cells and the interaction is enhanced by the addition of TCDD and Dex.
Taken together, these studies provide a molecular mechanism of crosstalk between AHR and GR in target gene expression in ARPE-19 cells.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jin, Hong Lan& Choi, Yujin& Jeong, Kwang Won. 2017. Crosstalk between Aryl Hydrocarbon Receptor and Glucocorticoid Receptor in Human Retinal Pigment Epithelial Cells. International Journal of Endocrinology،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1166433
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jin, Hong Lan…[et al.]. Crosstalk between Aryl Hydrocarbon Receptor and Glucocorticoid Receptor in Human Retinal Pigment Epithelial Cells. International Journal of Endocrinology No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1166433
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jin, Hong Lan& Choi, Yujin& Jeong, Kwang Won. Crosstalk between Aryl Hydrocarbon Receptor and Glucocorticoid Receptor in Human Retinal Pigment Epithelial Cells. International Journal of Endocrinology. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1166433
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1166433
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر